Technology Process of C22H26ClN5O2
There total 6 articles about C22H26ClN5O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(3-(4-chloro-3-methoxyphenyl)-1H-pyrazol-4-yl)pyridine; phenyl chloroformate;
With
triethylamine;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
N,N-diethylethylenediamine;
With
potassium carbonate;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1111/cbdd.12186
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 1 h / Reflux
2.1: potassium permanganate; pyridine / water / 37 h / 20 - 50 °C
3.1: acetyl chloride / 15 h / 0 - 20 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / -25 - 20 °C
5.1: 18 h / 20 °C
5.2: 20 °C
6.1: triethylamine / tetrahydrofuran / 2 h / 0 °C
6.2: 1 h / 20 °C
With
pyridine; potassium permanganate; potassium carbonate; triethylamine; acetyl chloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; water; acetone;
DOI:10.1111/cbdd.12186
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / -25 - 20 °C
2.1: 18 h / 20 °C
2.2: 20 °C
3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C
3.2: 1 h / 20 °C
With
triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran;
DOI:10.1111/cbdd.12186
