Technology Process of 3-bromo-3'-hydroxy-2',4-dimethyl-5-nitrostilbene
There total 10 articles about 3-bromo-3'-hydroxy-2',4-dimethyl-5-nitrostilbene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethylsilyl iodide;
In
chloroform-d1;
at 50 ℃;
for 28.5h;
Yield given;
DOI:10.1021/jo01294a035
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / nitromethane / 22 h / 70 °C
2: 95 percent / sodium borohydride / ethanol / 2 h / Ambient temperature
3: n-butyllithium / diethyl ether; hexane / 1.) -10 deg C, 1 h; 2.) r.t., 21 h
4: trimethylsilyl iodide / CDCl3 / 28.5 h / 50 °C
With
sodium tetrahydroborate; n-butyllithium; trimethylsilyl iodide;
In
diethyl ether; chloroform-d1; nitromethane; ethanol; hexane;
DOI:10.1021/jo01294a035
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / tetrahydrofuran / 168 h / Ambient temperature
2: 98 percent / nitromethane / 22 h / 70 °C
3: 95 percent / sodium borohydride / ethanol / 2 h / Ambient temperature
4: n-butyllithium / diethyl ether; hexane / 1.) -10 deg C, 1 h; 2.) r.t., 21 h
5: trimethylsilyl iodide / CDCl3 / 28.5 h / 50 °C
With
sodium tetrahydroborate; n-butyllithium; trimethylsilyl iodide;
In
tetrahydrofuran; diethyl ether; chloroform-d1; nitromethane; ethanol; hexane;
DOI:10.1021/jo01294a035
