9-HydroxyMethyl-10-hydroxy CaMptothecin

Base Information

• Chemical Name: 9-HydroxyMethyl-10-hydroxy CaMptothecin
• CAS No.: 175613-38-4
• Molecular Formula: C₂₁H₁₈N₂O₆
• Molecular Weight: 394.384
• Mol file: 175613-38-4.mol

Synonyms:

Chemical Property of 9-HydroxyMethyl-10-hydroxy CaMptothecin

Chemical Property:

• Melting Point: >213°C (dec.)
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly)

Purity/Quality:

9-Hydroxymethyl-10-hydroxyCamptothecin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 9-Hydroxymethyl-10-hydroxy Camptothecin, is a metabolite of Camptothecin (C175150), which is a topoisomerase inhibitor for cancer therapy.

Technology Process of 9-HydroxyMethyl-10-hydroxy CaMptothecin

There total 2 articles about 9-HydroxyMethyl-10-hydroxy CaMptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

topotecan (123948-87-8) + methyl trifluoromethanesulfonate (333-27-7) → 9-[(trimethylammonium)methyl]-10-hydroxy-20(S)-camptothecin triflate + C21H18N2O6 (175613-38-4) + CHF3O3S*C23H23N3O5 (1243272-93-6) + CF3O3S(1-)*C25H28N3O5(1+)

Guidance literature:

methyl trifluoromethanesulfonate; With potassium carbonate; In dichloromethane; for 0.5h;

topotecan; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/mrc.2625

Reference yield:

Methyl methanesulfonate (66-27-3) + topotecan (123948-87-8) → C21H18N2O6 (175613-38-4) + CH4O3S*C23H23N3O5 + CH3O3S(1-)*C25H28N3O5(1+) + 10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate (123948-98-1)

Guidance literature:

Methyl methanesulfonate; With potassium carbonate; In dichloromethane; for 0.5h;

topotecan; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/mrc.2625

upstream raw materials:

topotecan

methyl trifluoromethanesulfonate

Methyl methanesulfonate

Refernces