Ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxoquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxoquinoline-3-carboxylate
CAS No.:88569-33-9
Molecular Formula:C13H10 Cl F N2 O4
Molecular Weight:312.685
Hs Code.:
European Community (EC) Number:289-426-8
DSSTox Substance ID:DTXSID801008229
Nikkaji Number:J348.549H
Wikidata:Q83004622
Mol file:88569-33-9.mol

Synonyms:88569-33-9;Ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxoquinoline-3-carboxylate;EINECS 289-426-8;Ethyl 7-chloro-6-fluoro-1-formamido-4-oxo-1,4-dihydroquinoline-3-carboxylate;C13H10ClFN2O4;SCHEMBL10923543;JSRUDJNKLVNSGZ-UHFFFAOYSA-N;DTXSID801008229;C13-H10-Cl-F-N2-O4;AKOS000280470;[7-Chloro-3-(ethoxycarbonyl)-6-fluoro-4-oxoquinolin-1(4H)-yl]methanimidic acid;7-Chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester;ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Suppliers and Price of Ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxoquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxoquinoline-3-carboxylate

Chemical Property:

Vapor Pressure:8.64E-09mmHg at 25°C
Boiling Point:464°C at 760 mmHg
Flash Point:234.4°C
PSA：80.89000
Density:1.51g/cm³
LogP:2.32010
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:312.0313127
Heavy Atom Count:21
Complexity:485

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN(C2=CC(=C(C=C2C1=O)F)Cl)NC=O

Technology Process of Ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxoquinoline-3-carboxylate

There total 3 articles about Ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88569-30-6
ethyl 1-amino-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

: 2258-42-6
formyl acetic anhydride

: 88569-33-9
ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Guidance literature:: With acetic anhydride; In formic acid;

Reference yield:

: 75073-15-3
ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate

: 88569-33-9
ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / K₂CO₃, O-(2,4-dinitrophenyl)hydroxylamine / dimethylformamide / 3 h / Ambient temperature

2: 1.) acetic anhydride / 1.) 0-50 deg C, 30 min, 2.) 25 deg C, 3.5 d

With acetic anhydride; potassium carbonate; O-(2,4-dinitrophenyl)hydroxylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00375a003

Reference yield:

: 64-18-6
formic acid

: 88569-30-6
ethyl 1-amino-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

: 88569-33-9
ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Guidance literature:: With acetic anhydride; Yield given. Multistep reaction; 1.) 0-50 deg C, 30 min, 2.) 25 deg C, 3.5 d;
DOI:10.1021/jm00375a003