N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide methanesulfonate

Base Information

Chemical Name:N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide methanesulfonate
CAS No.:404844-03-7
Molecular Formula:CH₄O₃S*C₂₈H₂₉N₇O
Molecular Weight:575.692
Hs Code.:
European Community (EC) Number:875-601-1
ChEMBL ID:CHEMBL2386594

Synonyms:404844-03-7;N-Desmethyl imatinib (mesylate);CHEMBL2386594;Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-, monomethanesulfonate;methanesulfonic acid;N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-(piperazin-1-ylmethyl)benzamide;N-Desmethyl imatinib mesylate;N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide methanesulfonate;SCHEMBL4405514;HY-G0017A;AKOS015958629;N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-piperazin-1-ylmethyl-benzamide methanesulfonate;CS-0132786;VU0493838-1;F9995-0193

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide methanesulfonate

Chemical Property:

Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:7
Exact Mass:575.23147373
Heavy Atom Count:41
Complexity:771

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCNCC3)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

Technology Process of N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide methanesulfonate

There total 5 articles about N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-75-2,98527-29-8
methanesulfonic acid

: 404844-02-6
N-Desmethyl Imatinib

: 404844-03-7
N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]-4-(1-piperazinylmethyl)benzamide methanesulphonate

Guidance literature:: In ethanol; Heating;
DOI:10.1016/j.bmc.2013.03.038

Reference yield:

: 152460-10-1
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 404844-03-7
N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]-4-(1-piperazinylmethyl)benzamide methanesulphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane / 2.75 h / 22 - 34 °C

2: ethanol; water / 14 h / Reflux

3: ethanol / Heating

In 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmc.2013.03.038

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 404844-03-7
N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]-4-(1-piperazinylmethyl)benzamide methanesulphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane / 2.75 h / 22 - 34 °C

2: ethanol; water / 14 h / Reflux

3: ethanol / Heating

In 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmc.2013.03.038