7,8,9,10-Tetrahydro-N-butyl-6H-cyclohepta(b)quinolin-11-amine hydrochl oride

Base Information

• Chemical Name: 7,8,9,10-Tetrahydro-N-butyl-6H-cyclohepta(b)quinolin-11-amine hydrochl oride
• CAS No.: 28869-39-8
• Molecular Formula: C₁₈H₂₄N₂*ClH
• Molecular Weight: 304.863
• Hs Code.: 2933990090
• Mol file: 28869-39-8.mol

Synonyms:6H-Cyclohepta[b]quinolin-11-amine,N-butyl-7,8,9,10-tetrahydro-, monohydrochloride (9CI);6H-Cyclohepta[b]quinoline, 11-(butylamino)-7,8,9,10-tetrahydro-,monohydrochloride (8CI)

Chemical Property of 7,8,9,10-Tetrahydro-N-butyl-6H-cyclohepta(b)quinolin-11-amine hydrochl oride

Chemical Property:

• Vapor Pressure: 4.96E-08mmHg at 25°C
• Boiling Point: 442.6°Cat760mmHg
• Flash Point: 221.5°C
• PSA: 28.15000
• Density: g/cm³
• LogP: 4.93960

Purity/Quality:

7,8,9,10-TETRAHYDRO-N-BUTYL-6H-CYCLOHEPTA(B)QUINOLIN-11-AMINE HYDROCHL ORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,8,9,10-Tetrahydro-N-butyl-6H-cyclohepta(b)quinolin-11-amine hydrochl oride

There total 2 articles about 7,8,9,10-Tetrahydro-N-butyl-6H-cyclohepta(b)quinolin-11-amine hydrochl oride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

10-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[1,2-b]quinoline (5778-71-2) + N-butylamine (109-73-9,85404-21-3) → 4-n-Butylamino-2,3-pentamethylenequinoline hydrochloride (28869-39-8)

Guidance literature:

With phenol; at 145 - 150 ℃; for 20h;

Reference yield:

n-Butyl chloride (109-69-3) + 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylamine (5778-86-9) → 4-n-Butylamino-2,3-pentamethylenequinoline hydrochloride (28869-39-8)

Guidance literature:

With sodium hydride; Multistep reaction; 1.) DMF, 90 deg C, 1 h, 2.) DMF, 90 deg C, 3 h;

upstream raw materials:

n-Butyl chloride

7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylamine

10-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[1,2-b]quinoline

N-butylamine

Refernces