Technology Process of (3-methoxy[1,5]naphthyridin-4-yl)methanol
There total 8 articles about (3-methoxy[1,5]naphthyridin-4-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3-methoxy[1,5]naphthyridin-4-yl)methyl bromide;
With
potassium acetate;
In
N,N-dimethyl-formamide;
With
methanol; potassium carbonate;
In
N,N-dimethyl-formamide;
DOI:10.1021/op300064b
- Guidance literature:
-
With
methanol; potassium carbonate;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jm900729s
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -25 °C / Large scale reaction
2.2: 1 h / -70 - -65 °C
3.1: hydrogenchloride / methanol; water / 4 h / 45 °C / Large scale reaction
4.1: ferrous(II) sulfate heptahydrate; sodium 3-nitrobenzene sulfonate; sulfuric acid; boric acid / water / 6 h / 135 - 145 °C / Large scale reaction
5.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane
6.1: potassium acetate / N,N-dimethyl-formamide
With
hydrogenchloride; ferrous(II) sulfate heptahydrate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; N-Bromosuccinimide; n-butyllithium; sulfuric acid; sodium 3-nitrobenzene sulfonate; potassium acetate; boric acid; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dibenzoyl peroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; water; N,N-dimethyl-formamide;
4.1: Skraup reaction;
DOI:10.1021/op300064b
