Technology Process of (2S,4R)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-5,5,5-trifluor-4-methylvaleronitril
There total 10 articles about (2S,4R)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-5,5,5-trifluor-4-methylvaleronitril which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / H2 / Pd/C (10 percent Pd) / 6 h / Ambient temperature
2: 74 percent / LiAlH4 / diethyl ether / 2 h
3: 80 percent / PCC / CH2Cl2 / 1.5 h / Ambient temperature
4: ethane-1,2-diol / 0.25 h / Heating
With
lithium aluminium tetrahydride; hydrogen; pyridinium chlorochromate;
10% palladium on active carbon;
In
diethyl ether; dichloromethane; ethylene glycol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / H2 / Pd/C (10 percent Pd) / 6 h / Ambient temperature
2: 74 percent / LiAlH4 / diethyl ether / 2 h
3: 80 percent / PCC / CH2Cl2 / 1.5 h / Ambient temperature
4: ethane-1,2-diol / 0.25 h / Heating
With
lithium aluminium tetrahydride; hydrogen; pyridinium chlorochromate;
10% palladium on active carbon;
In
diethyl ether; dichloromethane; ethylene glycol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 74 percent / LiAlH4 / diethyl ether / 2 h
2: 80 percent / PCC / CH2Cl2 / 1.5 h / Ambient temperature
3: ethane-1,2-diol / 0.25 h / Heating
With
lithium aluminium tetrahydride; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; ethylene glycol;
