Technology Process of 1-((R)-5-Benzyloxy-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-3-ylmethyl)-4-methyl-piperazine
There total 11 articles about 1-((R)-5-Benzyloxy-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-3-ylmethyl)-4-methyl-piperazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 99 percent / KOH / methanol / 18 h / Ambient temperature
2: 1.) FeCl3, 2.) NaOH / 1.) dichloroethane, RT, 5 d, 2.) THF, MeOH, H2O, reflux, 6 h
3: 99 percent / K2CO3 / acetone / 39 h / Heating
4: tetrahydrofuran / 15 h / Ambient temperature
5: aq. NH4Cl, H2SO4 / tetrahydrofuran / 0 °C
6: 1.) BH3*DMS, 2.) 30percent aq. H2O2, NaOH / 1.) THF, RT, 15 h, 2.) THF, 20 deg C, 3 h
7: various solvent(s) / 24 h / Ambient temperature; Candida rugosa lipase (L-3)
8: K2CO3, MeOH / 5 h
9: 99 percent / Et3N / tetrahydrofuran / 3 h / Ambient temperature
10: K2CO3 / acetonitrile / 20 h / Heating
With
methanol; potassium hydroxide; sodium hydroxide; dimethylsulfide borane complex; sulfuric acid; dihydrogen peroxide; iron(III) chloride; potassium carbonate; ammonium chloride; triethylamine;
In
tetrahydrofuran; methanol; acetone; acetonitrile;
DOI:10.1016/S0957-4166(96)00494-6
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) FeCl3, 2.) NaOH / 1.) dichloroethane, RT, 5 d, 2.) THF, MeOH, H2O, reflux, 6 h
2: 99 percent / K2CO3 / acetone / 39 h / Heating
3: tetrahydrofuran / 15 h / Ambient temperature
4: aq. NH4Cl, H2SO4 / tetrahydrofuran / 0 °C
5: 1.) BH3*DMS, 2.) 30percent aq. H2O2, NaOH / 1.) THF, RT, 15 h, 2.) THF, 20 deg C, 3 h
6: various solvent(s) / 24 h / Ambient temperature; Candida rugosa lipase (L-3)
7: K2CO3, MeOH / 5 h
8: 99 percent / Et3N / tetrahydrofuran / 3 h / Ambient temperature
9: K2CO3 / acetonitrile / 20 h / Heating
With
methanol; sodium hydroxide; dimethylsulfide borane complex; sulfuric acid; dihydrogen peroxide; iron(III) chloride; potassium carbonate; ammonium chloride; triethylamine;
In
tetrahydrofuran; acetone; acetonitrile;
DOI:10.1016/S0957-4166(96)00494-6
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 99 percent / K2CO3 / acetone / 39 h / Heating
2: tetrahydrofuran / 15 h / Ambient temperature
3: aq. NH4Cl, H2SO4 / tetrahydrofuran / 0 °C
4: 1.) BH3*DMS, 2.) 30percent aq. H2O2, NaOH / 1.) THF, RT, 15 h, 2.) THF, 20 deg C, 3 h
5: various solvent(s) / 24 h / Ambient temperature; Candida rugosa lipase (L-3)
6: K2CO3, MeOH / 5 h
7: 99 percent / Et3N / tetrahydrofuran / 3 h / Ambient temperature
8: K2CO3 / acetonitrile / 20 h / Heating
With
methanol; sodium hydroxide; dimethylsulfide borane complex; sulfuric acid; dihydrogen peroxide; potassium carbonate; ammonium chloride; triethylamine;
In
tetrahydrofuran; acetone; acetonitrile;
DOI:10.1016/S0957-4166(96)00494-6
