(1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid

Base Information

Chemical Name:(1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid
CAS No.:1087347-12-3
Molecular Formula:C₄₀H₄₈Cl₂N₂O₇
Molecular Weight:739.736
Hs Code.:

(1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid

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Chemical Property of (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid

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Technology Process of (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid

There total 13 articles about (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1087347-11-2
ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate

: 1087347-12-3
(1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 75 ℃; for 18h;
DOI:10.1016/j.bmcl.2011.02.067

Reference yield:

: 109716-55-4
ethyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate

: 1087347-12-3
(1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 18 h / 80 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

3: sodium hydroxide / ethanol / 18 h / 75 °C

With hydrogenchloride; tributylphosphine; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.02.067

Reference yield:

: 1026786-87-7
3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

: 1087347-12-3
(1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: magnesium sulfate / dichloromethane / 12 h / 20 °C

2: sodium tetrahydroborate / methanol / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 18 h / 80 °C

7: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

8: sodium hydroxide / ethanol / 18 h / 75 °C

With hydrogenchloride; sodium tetrahydroborate; tributylphosphine; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; magnesium sulfate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2011.02.067