ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate

Base Information

Chemical Name:ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate
CAS No.:1087347-11-2
Molecular Formula:C₄₂H₅₂Cl₂N₂O₇
Molecular Weight:767.79
Hs Code.:

ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate

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Chemical Property of ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate

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Technology Process of ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate

There total 13 articles about ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1303607-08-0
C₄₇H₆₀Cl₂N₂O₉

: 1087347-11-2
ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2011.02.067

Reference yield:

: 109716-55-4
ethyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate

: 1087347-11-2
ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 18 h / 80 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.02.067

Reference yield:

: 1026786-87-7
3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

: 1087347-11-2
ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: magnesium sulfate / dichloromethane / 12 h / 20 °C

2: sodium tetrahydroborate / methanol / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 18 h / 80 °C

7: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; sodium tetrahydroborate; tributylphosphine; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; magnesium sulfate; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2011.02.067