diethyl 1,2-diphenyl-1,2-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 1,2-diphenyl-1,2-dihydropyridine-3,5-dicarboxylate
• CAS No.: 1446307-49-8
• Molecular Formula: C₂₃H₂₃NO₄
• Molecular Weight: 377.44
• Mol file: 1446307-49-8.mol

Synonyms:

Chemical Property of diethyl 1,2-diphenyl-1,2-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1,2-diphenyl-1,2-dihydropyridine-3,5-dicarboxylate

There total 4 articles about diethyl 1,2-diphenyl-1,2-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

benzaldehyde (100-52-7) + aniline (62-53-3) + propynoic acid ethyl ester (623-47-2) → diethyl 1,2-diphenyl-1,2-dihydropyridine-3,5-dicarboxylate (1446307-49-8) + diethyl 1-phenyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate (83300-81-6)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 8h; Solvent; Reagent/catalyst; chemoselective reaction; Inert atmosphere; Reflux;

DOI:10.1039/d0ob02289f

Reference yield: 46.0%

benzaldehyde (100-52-7) + aniline (62-53-3) + propynoic acid ethyl ester (623-47-2) → diethyl 1,2-diphenyl-1,2-dihydropyridine-3,5-dicarboxylate (1446307-49-8)

Guidance literature:

benzaldehyde; aniline; With toluene-4-sulfonic acid; In ethanol; Microwave irradiation; Reflux;

propynoic acid ethyl ester; With aniline; In ethanol; for 1h; chemoselective reaction; Microwave irradiation; Heating;

DOI:10.1039/d0ob02289f

Reference yield:

propynoic acid ethyl ester (623-47-2) → diethyl 1,2-diphenyl-1,2-dihydropyridine-3,5-dicarboxylate (1446307-49-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.17 h / 0 - 20 °C / Inert atmosphere

2: benzene / 4 h / Reflux

3: trifluoroacetic acid / acetonitrile / 20 °C / Inert atmosphere

With trifluoroacetic acid; In tetrahydrofuran; acetonitrile; benzene;

DOI:10.1016/j.tetlet.2013.05.037

upstream raw materials:

propynoic acid ethyl ester

ethyl 3-(allylamino)acrylate

benzaldehyde

aniline