(S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester

Base Information

• Chemical Name: (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester
• CAS No.: 175288-54-7
• Molecular Formula: C₃₆H₄₃NO₃S₂Si
• Molecular Weight: 629.96
• Mol file: 175288-54-7.mol

Synonyms:

Chemical Property of (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester

There total 5 articles about (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

i-propyl(2-(hydroxy)ethyl)amine (109-56-8) → (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester (175288-54-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / Et₃N, DMAP / CH₂Cl₂ / 12 h / Heating

2: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 1.) NaH / 1.) THF, RT, 2.) THF, reflux, 16 h

4: 1.) TMEDA, sec-BuLi

With dmap; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; triethylamine; In dichloromethane;

DOI:10.1055/s-1996-4163

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester (175288-54-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / Et₃N, DMAP / CH₂Cl₂ / 12 h / Heating

2: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 1.) NaH / 1.) THF, RT, 2.) THF, reflux, 16 h

4: 1.) TMEDA, sec-BuLi

With dmap; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; triethylamine; In dichloromethane;

DOI:10.1055/s-1996-4163

Reference yield:

N-<2-(tert-butyldiphenylsilyloxy)ethyl>-N-isopropylamine (175288-41-2) → (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester (175288-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

2: 1.) NaH / 1.) THF, RT, 2.) THF, reflux, 16 h

3: 1.) TMEDA, sec-BuLi

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; triethylamine; In dichloromethane;

DOI:10.1055/s-1996-4163

upstream raw materials:

i-propyl(2-(hydroxy)ethyl)amine

(R)-1-(2-Naphthyl)ethanol

tert-butylchlorodiphenylsilane

N-<2-(tert-butyldiphenylsilyloxy)ethyl>-N-isopropylamine