1-Hydroxy-2-methylthio-1-phenylethanphosphonsaeurediethylester

Base Information

• Chemical Name: 1-Hydroxy-2-methylthio-1-phenylethanphosphonsaeurediethylester
• CAS No.: 76387-53-6
• Molecular Formula: C₁₃H₂₁O₄PS
• Molecular Weight: 304.347
• Mol file: 76387-53-6.mol

Synonyms:

Chemical Property of 1-Hydroxy-2-methylthio-1-phenylethanphosphonsaeurediethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-Hydroxy-2-methylthio-1-phenylethanphosphonsaeurediethylester

There total 1 articles about 1-Hydroxy-2-methylthio-1-phenylethanphosphonsaeurediethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylthio-1-phenyl-ethanone (5398-93-6) + diethyl trimethylsilyl phosphite (13716-45-5) → 1-Hydroxy-2-methylthio-1-phenylethanphosphonsaeurediethylester (76387-53-6)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1) 120 deg C, 1.5 h, 2) ethanol, 48 h;

DOI:10.1007/BF00909658

Reference yield:

1-Hydroxy-2-methylthio-1-phenylethanphosphonsaeurediethylester (76387-53-6) → phosphoric acid diethyl ester-(1-phenyl-vinyl ester) (1021-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / -27 deg C to RT, 2 h

2: NaN(SiMe₃)2 / dimethylsulfoxide; toluene / 2.5 h / Ambient temperature

With sodium hexamethyldisilazane; In dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1007/BF00909658

Reference yield:

Methyl fluorosulfonate (421-20-5) + 1-Hydroxy-2-methylthio-1-phenylethanphosphonsaeurediethylester (76387-53-6) → C14H24O4PS(1+)*FO3S(1-)

Guidance literature:

In dichloromethane; -27 deg C to RT, 2 h;

DOI:10.1007/BF00909658

upstream raw materials:

2-methylthio-1-phenyl-ethanone

diethyl trimethylsilyl phosphite

Downstream raw materials:

phosphoric acid diethyl ester-(1-phenyl-vinyl ester)

Refernces