2,4,6-trimethylbenzhydrol

Base Information

• Chemical Name: 2,4,6-trimethylbenzhydrol
• CAS No.: 1517-60-8
• Molecular Formula: C₁₆H₁₈O
• Molecular Weight: 226.318
• Mol file: 1517-60-8.mol

Synonyms:

Chemical Property of 2,4,6-trimethylbenzhydrol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-trimethylbenzhydrol

There total 26 articles about 2,4,6-trimethylbenzhydrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

2,4,6-Trimethylbenzophenon (954-16-5) → 2,4,6-trimethylbenzhydrol (1517-60-8,1573-05-3,32189-55-2,21945-75-5)

Guidance literature:

With LDPA; In tetrahydrofuran; at 61 ℃; for 66h;

DOI:10.1021/jo00074a014

Reference yield: 96.0%

2,4,6-trimethylphenyl bromide (576-83-0) + benzaldehyde (100-52-7) → 2,4,6-trimethylbenzhydrol (1517-60-8,1573-05-3,32189-55-2,21945-75-5)

Guidance literature:

With nickel(II) bromide 2-methoxyethyl ether complex; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc; In tetrahydrofuran; at 60 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1021/jacs.8b13709

Reference yield: 94.0%

mesytaldehyde (487-68-3) + phenylboronic acid (98-80-6) → 2,4,6-trimethylbenzhydrol (1517-60-8,1573-05-3,32189-55-2,21945-75-5)

Guidance literature:

With potassium tert-butylate; RhCl(COD)(1,3-dialkyl-3,4,5,6-tetrahydropyrimidin-2-ylidene); In 1,2-dimethoxyethane; water; at 80 ℃; for 4h;

DOI:10.1016/j.jorganchem.2005.07.085

upstream raw materials:

2,4,6-Trimethylbenzophenon

benzaldehyde

2-mesitylmagnesium bromide

1-hexene

Downstream raw materials:

(+/-)-phthalic acid mono-(2,4,6-trimethyl-benzhydryl ester)

bis-(2,4,6-trimethyl-benzhydryl)-ether

2,4,6-trimethyl-benzhydryl chloride

2,4,6-Trimethyl-benzhydrol

Refernces

• 1、 Sai, Masahiro. "An Efficient Ga(OTf)3/Isopropanol Catalytic System for Direct Reduction of Benzylic Alcohols". supporting information. p. 4330 - 4335. Retrieved 2018/10/15.
• 2、 Denizalti, Serpil,Türkmen, Hayati,?etinkaya, Bekir. "Chelating alkoxy NHC-Rh(I) complexes and their applications in the arylation of aldehydes". supporting information. p. 4129 - 4132. Retrieved 2014/07/22.