1-{N-cyano-N'-[(5R)-2c-(2,2-dimethyl-propionyloxymethoxycarbonyl)-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-carbamimidoylmethyl}-4-(4-nitro-benzyl)-pyridinium; chloride

Base Information

• Chemical Name: 1-{N-cyano-N'-[(5R)-2c-(2,2-dimethyl-propionyloxymethoxycarbonyl)-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-carbamimidoylmethyl}-4-(4-nitro-benzyl)-pyridinium; chloride
• CAS No.: 51742-79-1
• Molecular Formula: C₂₉H₃₃N₆O₇S*Cl
• Molecular Weight: 645.136
• Mol file: 51742-79-1.mol

Synonyms:

Chemical Property of 1-{N-cyano-N'-[(5R)-2c-(2,2-dimethyl-propionyloxymethoxycarbonyl)-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-carbamimidoylmethyl}-4-(4-nitro-benzyl)-pyridinium; chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{N-cyano-N'-[(5R)-2c-(2,2-dimethyl-propionyloxymethoxycarbonyl)-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-carbamimidoylmethyl}-4-(4-nitro-benzyl)-pyridinium; chloride

There total 2 articles about 1-{N-cyano-N'-[(5R)-2c-(2,2-dimethyl-propionyloxymethoxycarbonyl)-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-carbamimidoylmethyl}-4-(4-nitro-benzyl)-pyridinium; chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-aminopenicillanic acid pivaloyloxymethyl ester (25031-08-7) → 1-{N-cyano-N'-[(5R)-2c-(2,2-dimethyl-propionyloxymethoxycarbonyl)-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-carbamimidoylmethyl}-4-(4-nitro-benzyl)-pyridinium; chloride (51742-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: acetone

In diethyl ether; acetone;

DOI:10.1021/jm00247a017

Reference yield:

4-Nitrobenzylpyridin (1083-48-3) + 6β-[(2-chloro-N-cyano-acetimidoyl)-amino]-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester (51687-75-3) → 1-{N-cyano-N'-[(5R)-2c-(2,2-dimethyl-propionyloxymethoxycarbonyl)-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-carbamimidoylmethyl}-4-(4-nitro-benzyl)-pyridinium; chloride (51742-79-1)

Guidance literature:

In acetone;

DOI:10.1021/jm00247a017

upstream raw materials:

4-Nitrobenzylpyridin

6β-[(2-chloro-N-cyano-acetimidoyl)-amino]-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester

6-aminopenicillanic acid pivaloyloxymethyl ester