6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

Base Information

Chemical Name:6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid
CAS No.:83081-89-4
Molecular Formula:2C₄H₆O₆*C₂₃H₃₂N₄O
Molecular Weight:680.709
Hs Code.:

6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

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Chemical Property of 6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

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Technology Process of 6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

There total 4 articles about 6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5464-78-8
1-(2-methoxyphenyl)piperazine hydrochloride

: 83081-89-4
6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / pyridine / CHCl₃ / 1.) 5 deg C; 2.) r.t.

2: Triton B / ethanol / Heating

3: LiAlH₄ / 1.) ether, reflux; 2.) acetone

With pyridine; lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; In ethanol; chloroform;
DOI:10.1248/cpb.32.3981

Reference yield:

: 96743-74-7
4-methacryloyl-4-(2-methoxyphenyl)piperazine

: 83081-89-4
6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Triton B / ethanol / Heating

2: LiAlH₄ / 1.) ether, reflux; 2.) acetone

With lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; In ethanol;
DOI:10.1248/cpb.32.3981

Reference yield:

: 80957-68-2
5,6,7,8-tetrahydro-1,6-naphthyridine

: 83081-89-4
6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-methyl-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Triton B / ethanol / Heating

2: LiAlH₄ / 1.) ether, reflux; 2.) acetone

With lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; In ethanol;
DOI:10.1248/cpb.32.3981