2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde

Base Information

Chemical Name:2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde
CAS No.:882512-75-6
Molecular Formula:C₁₈H₂₆O₃
Molecular Weight:290.403
Hs Code.:

Synonyms:

Suppliers and Price of 2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde

There total 19 articles about 2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77879-82-4
2-allyl-4-methyl-6-methoxyphenol

: 882512-75-6
2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 15 steps

1.1: 95 percent / KOH / methanol / 10 h / Heating

2.1: 96 percent / sodium hydroxyde / H₂O / 1 h / Heating

3.1: NaHCO₃; ozone / methanol; CH₂Cl₂ / 0.22 h / -70 °C

3.2: 80 percent / dimethyl sulfide / methanol; CH₂Cl₂ / 8 h / 20 °C

4.1: Mg; iodine / diethyl ether

4.2: 88 percent / diethyl ether / 3 h / 20 °C

5.1: 96 percent / PCC; silica gel / CH₂Cl₂ / 2 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.67 h / 20 °C

6.2: tetrahydrofuran; various solvent(s) / 10 h / 20 °C

6.3: 91 percent / tetrahydrofuran; various solvent(s) / 0.5 h / 180 °C

7.1: 90 percent / tetrahydrofuran / 2 h / sonication

8.1: 97 percent / hydrogen / Pd-CaCO₃ / ethanol / 24 h / 20 °C

9.1: 85 percent / PCC; silica gel / CH₂Cl₂ / 30 h / 20 °C

10.1: 75 percent / sodium borohydride / methanol / 1.5 h / cooling

11.1: 28 percent / propionic acid / 48 h / 180 °C

12.1: 80 percent / Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂ / 6 h / 20 °C

13.1: 99 percent / hydrogen / Pd on activated C / ethanol / 3 h / 20 °C / 760 Torr

14.1: 98 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

15.1: 89 percent / PCC; silica gel / CH₂Cl₂ / 0.5 h / 20 °C

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; iodine; silica gel; sodium hydride; sodium hydrogencarbonate; ozone; magnesium; propionic acid; pyridinium chlorochromate; palladium on activated charcoal; Grubbs catalyst first generation; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; 4.2: Grignard reaction / 11.1: Claisen orthoester rearrangement;
DOI:10.1016/j.tet.2006.01.021

Reference yield:

: 882512-69-8
1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-one

: 882512-75-6
2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.67 h / 20 °C

1.2: tetrahydrofuran; various solvent(s) / 10 h / 20 °C

1.3: 91 percent / tetrahydrofuran; various solvent(s) / 0.5 h / 180 °C

2.1: 90 percent / tetrahydrofuran / 2 h / sonication

3.1: 97 percent / hydrogen / Pd-CaCO₃ / ethanol / 24 h / 20 °C

4.1: 85 percent / PCC; silica gel / CH₂Cl₂ / 30 h / 20 °C

5.1: 75 percent / sodium borohydride / methanol / 1.5 h / cooling

6.1: 28 percent / propionic acid / 48 h / 180 °C

7.1: 80 percent / Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂ / 6 h / 20 °C

8.1: 99 percent / hydrogen / Pd on activated C / ethanol / 3 h / 20 °C / 760 Torr

9.1: 98 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

10.1: 89 percent / PCC; silica gel / CH₂Cl₂ / 0.5 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; silica gel; sodium hydride; propionic acid; pyridinium chlorochromate; palladium on activated charcoal; Grubbs catalyst first generation; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 6.1: Claisen orthoester rearrangement;
DOI:10.1016/j.tet.2006.01.021

Reference yield:

: 882512-68-7
1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-ol

: 882512-75-6
2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 11 steps

1.1: 96 percent / PCC; silica gel / CH₂Cl₂ / 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.67 h / 20 °C

2.2: tetrahydrofuran; various solvent(s) / 10 h / 20 °C

2.3: 91 percent / tetrahydrofuran; various solvent(s) / 0.5 h / 180 °C

3.1: 90 percent / tetrahydrofuran / 2 h / sonication

4.1: 97 percent / hydrogen / Pd-CaCO₃ / ethanol / 24 h / 20 °C

5.1: 85 percent / PCC; silica gel / CH₂Cl₂ / 30 h / 20 °C

6.1: 75 percent / sodium borohydride / methanol / 1.5 h / cooling

7.1: 28 percent / propionic acid / 48 h / 180 °C

8.1: 80 percent / Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂ / 6 h / 20 °C

9.1: 99 percent / hydrogen / Pd on activated C / ethanol / 3 h / 20 °C / 760 Torr

10.1: 98 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

11.1: 89 percent / PCC; silica gel / CH₂Cl₂ / 0.5 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; silica gel; sodium hydride; propionic acid; pyridinium chlorochromate; palladium on activated charcoal; Grubbs catalyst first generation; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 7.1: Claisen orthoester rearrangement;
DOI:10.1016/j.tet.2006.01.021