1H-imidazo[4,5-b]phenazine

Base Information

• Chemical Name: 1H-imidazo[4,5-b]phenazine
• CAS No.: 259-33-6
• Molecular Formula: C₁₃H₈N₄
• Molecular Weight: 220.233
• European Community (EC) Number: 636-767-9
• Nikkaji Number: J1.205.335E
• ChEMBL ID: CHEMBL1481417
• Mol file: 259-33-6.mol

Synonyms:1H-imidazo[4,5-b]phenazine;1H-Imidazo(4,5-b)phenazine;MLS000700045;SMR000226252;CBDivE_015802;CHEMBL1481417;SCHEMBL15010385;BDBM52505;cid_5998849;HMS2619H08;AKOS002346523;VU0279259-2;SR-01000718137;SR-01000718137-2

Chemical Property of 1H-imidazo[4,5-b]phenazine

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 220.074896272
• Heavy Atom Count: 17
• Complexity: 522

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)NC3=CC4=NC=NC4=CC3=N2

Technology Process of 1H-imidazo[4,5-b]phenazine

There total 4 articles about 1H-imidazo[4,5-b]phenazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,3-diaminephenazine (655-86-7) + orthoformic acid triethyl ester (122-51-0) → 1H-imidazo[4,5-b]phenazine (259-33-6)

Guidance literature:

In acetic acid; for 7h; Reagent/catalyst; Time; Reflux;

DOI:10.1016/j.ejmech.2013.12.007

Reference yield: 62.0%

formic acid (64-18-6) + 2,3-diaminephenazine (655-86-7) → 1H-imidazo[4,5-b]phenazine (259-33-6)

Guidance literature:

With sodium acetate; for 10h; Heating;

DOI:10.1007/PL00010183

Reference yield: 43.0%

1H-Imidazo[4,5-b]phenazine-2-thiol (96235-35-7) → 1H-imidazo[4,5-b]phenazine (259-33-6)

Guidance literature:

With rose bengal; water; oxygen; sodium chloride; In N,N-dimethyl-formamide; at 25 ℃; for 48h; Irradiation; Green chemistry;

DOI:10.1039/d0gc02269a

upstream raw materials:

formic acid

2,3-diaminephenazine

orthoformic acid triethyl ester

1H-Imidazo[4,5-b]phenazine-2-thiol

Refernces

• 1、 Mahran, Asma M.,Ragab, Sherif Sh.,Hashem, Ahmed I.,Ali, Mamdouh M.,Nada, Afaf A.. "Synthesis and antiproliferative activity of novel polynuclear heterocyclic compounds derived from 2,3-diaminophenazine". . p. 568 - 576. Retrieved 2015/02/19.