1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon

Base Information

• Chemical Name: 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon
• CAS No.: 134746-55-7
• Molecular Formula: C₃₄H₃₇NO₂SeSi
• Molecular Weight: 598.719
• Mol file: 134746-55-7.mol

Synonyms:

Chemical Property of 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon

There total 4 articles about 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-5-hydroxypiperidin-2-one (24211-54-9) → 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon (134746-55-7,134780-49-7)

Guidance literature:

Multi-step reaction with 4 steps

1: KOH / dimethylsulfoxide

2: H₂ / Pd/C

3: imidazole / dimethylformamide / Heating

4: 1) LDA / 1) THF, hexane, -78 deg C, 30 min, 2) THF, - 78 deg C, 2 h

With 1H-imidazole; potassium hydroxide; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/ardp.19913240503

Reference yield:

(S)-1-benzyl-5-(benzyloxy)piperidin-2-one (87179-79-1) → 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon (134746-55-7,134780-49-7)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: imidazole / dimethylformamide / Heating

3: 1) LDA / 1) THF, hexane, -78 deg C, 30 min, 2) THF, - 78 deg C, 2 h

With 1H-imidazole; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1002/ardp.19913240503

Reference yield:

(S)-1-benzyl-5-hydroxypiperidin-2-one (87179-80-4) → 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon (134746-55-7,134780-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / Heating

2: 1) LDA / 1) THF, hexane, -78 deg C, 30 min, 2) THF, - 78 deg C, 2 h

With 1H-imidazole; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1002/ardp.19913240503

upstream raw materials:

(S)-5-hydroxypiperidin-2-one

(S)-1-benzyl-5-hydroxypiperidin-2-one

(S)-1-benzyl-5-(benzyloxy)piperidin-2-one

tert-butylchlorodiphenylsilane

Downstream raw materials:

1-Benzyl-5S-t-butyldiphenylsiloxy-3,4-dehydro-2-piperidon

Refernces