(S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide

Base Information

• Chemical Name: (S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide
• CAS No.: 1027846-35-0
• Molecular Formula: C₂₈H₃₃N₃O
• Molecular Weight: 427.59
• Mol file: 1027846-35-0.mol

Synonyms:

Chemical Property of (S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide

There total 7 articles about (S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-bis(benzyliden)ethylendiamine (104-71-2) → (S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide (1027846-35-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH₄ / methanol / 3 h / 0 °C

2: 90 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

3: 1.) Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C, 4 h

4: H₂ / 10percent Pd/C / methanol / 2 h / Ambient temperature

With sodium tetrahydroborate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397919408011196

Reference yield:

benzyl bromide (100-39-0) → (S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide (1027846-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 7 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 2 h / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397919408011196

Reference yield:

benzaldehyde (100-52-7) → (S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide (1027846-35-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH₄ / methanol / 3 h / 0 °C

2: 90 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

3: 1.) Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C, 4 h

4: H₂ / 10percent Pd/C / methanol / 2 h / Ambient temperature

With sodium tetrahydroborate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397919408011196

upstream raw materials:

(S)-<1,2-(N-benzyl-N,N-diibenzyl)diaminoethane>-N^α-(benzyloxycarbonyl)prolinamide

N,N'-bis(benzyliden)ethylendiamine

1,2-(N-benzyl-N'-dibenzyl)diaminoethane

benzyl bromide