C₂₅H₂₄FNO₄

Base Information

• Chemical Name: C₂₅H₂₄FNO₄
• CAS No.: 1374226-59-1
• Molecular Formula: C₂₅H₂₄FNO₄
• Molecular Weight: 421.468
• Mol file: 1374226-59-1.mol

Synonyms:

Chemical Property of C₂₅H₂₄FNO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₄FNO₄

There total 6 articles about C₂₅H₂₄FNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3-(2,5-dimethylphenyl)-4-hydroxy-1-azaspiro[4.5]dec-3-ene-2,8-dione (1285685-19-9) + 4-Fluorophenylacetyl chloride (459-04-1) → C25H24FNO4 (1374226-59-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jf3002069

Reference yield:

methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate (907187-56-8) → C25H24FNO4 (1374226-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 90 °C

2: hydrogenchloride / water / 2 h / 60 °C

3: dmap; triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; dmap; potassium tert-butylate; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; 1: Dieckmann reaction;

DOI:10.1021/jf3002069

Reference yield:

8-amino-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid (54621-18-0) → C25H24FNO4 (1374226-59-1)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / 7 h / 0 °C / Reflux

2: potassium carbonate / acetonitrile / 3 h / 20 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 90 °C

4: hydrogenchloride / water / 2 h / 60 °C

5: dmap; triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; dmap; potassium tert-butylate; potassium carbonate; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3: Dieckmann reaction;

DOI:10.1021/jf3002069

upstream raw materials:

cyclohexanedione monoethylene ketal

methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate

3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one

3-(2,5-dimethylphenyl)-4-hydroxy-1-azaspiro[4.5]dec-3-ene-2,8-dione

Refernces