Technology Process of 2-Chloro-5-methyl-3-phenyl-pyrazine 1-oxide
There total 7 articles about 2-Chloro-5-methyl-3-phenyl-pyrazine 1-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
maleic anhydride; dihydrogen peroxide;
In
chloroform;
1.) room temperature, overnight; 2.) reflux, 3 h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 51 percent / PCl5, POCl3 / 1 h / 140 °C / Heating; sealed tube
2: 18 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) room temperature, overnight; 2.) reflux, 3 h
3: 95 percent / tetrakis(triphenylphosphine)palladium, sodium formate / dimethylformamide / 2 h / 100 °C
4: 29 percent / POCl3 / 1 h / Heating
5: 17 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) room temperature, overnight; 2.) reflux, 3 h
With
maleic anhydride; tetrakis(triphenylphosphine) palladium(0); phosphorus pentachloride; dihydrogen peroxide; sodium formate; trichlorophosphate;
In
chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / tetrakis(triphenylphosphine)palladium, sodium formate / dimethylformamide / 2 h / 100 °C
2: 31 percent / POCl3 / 1 h / Heating
3: 74 percent / H2, sodium acetate / 20percent Pd carbon / ethanol
4: 79 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) overnight; 2.) reflux, 4 h
5: 22 percent / POCl3 / 0.5 h / Heating
6: 17 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) room temperature, overnight; 2.) reflux, 3 h
With
maleic anhydride; tetrakis(triphenylphosphine) palladium(0); hydrogen; dihydrogen peroxide; sodium formate; sodium acetate; trichlorophosphate;
palladium on activated charcoal;
In
ethanol; chloroform; N,N-dimethyl-formamide;
