(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-((3S,6S)-1-oxaspiro[2.5]octan-6-yl)cyclohex-3-enecarboxamide

Base Information

Chemical Name:(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-((3S,6S)-1-oxaspiro[2.5]octan-6-yl)cyclohex-3-enecarboxamide
CAS No.:1562406-69-2
Molecular Formula:C₂₅H₃₃NO₂S
Molecular Weight:411.609
Hs Code.:

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Chemical Property of (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-((3S,6S)-1-oxaspiro[2.5]octan-6-yl)cyclohex-3-enecarboxamide

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Technology Process of (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-((3S,6S)-1-oxaspiro[2.5]octan-6-yl)cyclohex-3-enecarboxamide

There total 7 articles about (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-((3S,6S)-1-oxaspiro[2.5]octan-6-yl)cyclohex-3-enecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314795-38-4
4-bromo-2-(3,3-dimethylbut-1-ynyl)thiophene

: 1562406-69-2
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-((3S,6S)-1-oxaspiro[2.5]octan-6-yl)cyclohex-3-enecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; caesium carbonate; 2-acetylcyclohexanone / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere; Sealed tube

2.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.42 h / 0 - 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 45 °C

4.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C / Cooling with ice

4.2: 0.75 h / 20 °C

With hydrogenchloride; copper(l) iodide; 2-acetylcyclohexanone; water; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 78-79-5,9003-31-0
isoprene

: 1562406-69-2
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-((3S,6S)-1-oxaspiro[2.5]octan-6-yl)cyclohex-3-enecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium tetrachloride / dichloromethane / -10 - -9 °C / Large scale

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 - 27 °C / Large scale

3.1: potassium phosphate; N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.42 h / 0 - 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 45 °C

6.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C / Cooling with ice

6.2: 0.75 h / 20 °C

With hydrogenchloride; potassium phosphate; oxalyl dichloride; lithium hydroxide monohydrate; water; titanium tetrachloride; sodium hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; 1.1: |Diels-Alder Cycloaddition;

Reference yield:

: 121424-36-0
(+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid

: 1562406-69-2
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-((3S,6S)-1-oxaspiro[2.5]octan-6-yl)cyclohex-3-enecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.42 h / 0 - 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 45 °C

4.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C / Cooling with ice

4.2: 0.75 h / 20 °C

With hydrogenchloride; potassium phosphate; oxalyl dichloride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;