3β-benzoyloxy-8-azabicyclo[3.2.1]octane

Base Information

• Chemical Name: 3β-benzoyloxy-8-azabicyclo[3.2.1]octane
• CAS No.: 123202-90-4
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 123202-90-4.mol

Synonyms:

Chemical Property of 3β-benzoyloxy-8-azabicyclo[3.2.1]octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-benzoyloxy-8-azabicyclo[3.2.1]octane

There total 30 articles about 3β-benzoyloxy-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Tropacocaine hydrochloride (637-23-0) → Nortropacocaine (18470-33-2,20811-95-4,123202-90-4)

Guidance literature:

With sodium perchlorate; water; sodium carbonate; pH=10; pH-value; Electrochemical reaction; Green chemistry;

DOI:10.1039/d0gc00851f

Reference yield: 61.0%

endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester (19145-60-9) → 3β-benzoyloxy-8-azabicyclo[3.2.1]octane (18470-33-2,20811-95-4,123202-90-4)

Guidance literature:

endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; In toluene; at 20 - 100 ℃; for 16h;

With acetic acid; zinc;

Reference yield: 61.0%

endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester (19145-60-9) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 3β-benzoyloxy-8-azabicyclo[3.2.1]octane (18470-33-2,20811-95-4,123202-90-4)

Guidance literature:

endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; 2,2,2-Trichloroethyl chloroformate; With acetic acid; zinc; In toluene; at 20 - 100 ℃; for 16h;

With acetic acid; zinc; for 3h;

upstream raw materials:

N-<(benzyloxy)carbonyl>nortropacocaine

tropacocain

benzoyl chloride

pseudotropine

Downstream raw materials:

tropacocain

3α-benzoyloxy-8-phenetyl-8-azabicyclo[3.2.1]octane

3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane

(1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate