N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

Base Information

• Chemical Name: N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide
• CAS No.: 1331868-40-6
• Molecular Formula: C₂₃H₁₈ClF₃N₄O₂S
• Molecular Weight: 506.936
• Mol file: 1331868-40-6.mol

Synonyms:

Chemical Property of N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

There total 5 articles about N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H7BrClF3N2O (1331868-58-6) + 1-(4-methoxyphenyl)-2,3-dihydro-1H-1,3-benzodiazole-2-thione (26495-07-8) → N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide (1331868-40-6)

Guidance literature:

1-(4-methoxyphenyl)-2,3-dihydro-1H-1,3-benzodiazole-2-thione; With potassium hydroxide; In ethanol; for 2h; Reflux;

C₉H₇BrClF₃N₂O; In ethanol; at 20 ℃;

DOI:10.1021/ml200125r

Reference yield:

2-nitro-4'-methoxydiphenylamine (54381-13-4) → N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide (1331868-40-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 2068.65 Torr

2.1: dichloromethane / 0.5 h / 0 °C

3.1: potassium hydroxide / ethanol / 2 h / Reflux

3.2: 20 °C

With palladium 10% on activated carbon; hydrogen; potassium hydroxide; In methanol; ethanol; dichloromethane;

DOI:10.1021/ml200125r

Reference yield:

N-(4-methoxyphenyl)benzene-1,2-diamine (25914-22-1) → N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide (1331868-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 0.5 h / 0 °C

2.1: potassium hydroxide / ethanol / 2 h / Reflux

2.2: 20 °C

With potassium hydroxide; In ethanol; dichloromethane;

DOI:10.1021/ml200125r

upstream raw materials:

C₉H₇BrClF₃N₂O

1-(4-methoxyphenyl)-2,3-dihydro-1H-1,3-benzodiazole-2-thione

2-nitro-4'-methoxydiphenylamine

N-(4-methoxyphenyl)benzene-1,2-diamine