26495-07-8

Usage

InChI:InChI=1/C14H12N2OS/c1-17-11-8-6-10(7-9-11)16-13-5-3-2-4-12(13)15-14(16)18/h2-9H,1H3,(H,15,18)

Upstream product

• 98-95-3 nitrobenzene 
• 75-15-0 carbon disulfide 
• 1493-27-2 ortho-nitrofluorobenzene 
• 104-94-9 4-methoxy-aniline 
• 25914-22-1 N-(4-methoxyphenyl)benzene-1,2-diamine 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 54381-13-4 2-nitro-4'-methoxydiphenylamine 

Downstream Products

• 1331868-40-6 N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-43-9 N-(3,5-dichloro-6-methylpyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-44-0 N-(5-chloropyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-45-1 N-(3,5-dibromo-6-methylpyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-46-2 N-(3-chloro-5-methylpyridin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-50-8 N-(5,6-dimethyl-1,2,4-triazin-3-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-49-5 N-(1,3-dimethyl-1H-pyrazol-5-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-51-9 N-(4-chloro-6-methylpyrimidin-2-yl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-52-0 2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)-N-(4-methylthiazol-2-yl)propanamide 
• 1331868-54-2 N-(2,5-dibromophenyl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1331868-55-3 N-(2-chloro-4-methylphenyl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 742092-83-7 C₂₂H₁₈Cl₂N₄O₂S 
• 1331868-33-7 JMN₃-004 
• 1331868-34-8 N-(2-chloro-4-methylphenyl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)sulfonyl)propanamide 

Relevant academic research and scientific papers

A New Approach to the Synthesis of 1-Arylbenzimidazole-2-thiones from Nitroarenes and Anilines through Halogen-Free Substitution of Hydrogen via Iminophosphorane Intermediates

2-(Arylamino)phenyliminophosphoranes, formed directly from 2-nitrosodiarylamines, undergo a high-yielding cyclocondensation with CS2, providing a variety of 1-arylbenzimidazole-2-thiones. The reaction concludes a new synthetic route leading to the title compounds from simple nitroarenes and arylamines. The protocol is superior to common methods that use N-arylarylenediamines because it omits the SNAr substitution of halogen atoms in ortho-halonitroarenes, as well as reduction processes required for the synthesis of the intermediate diamines.

Imidazolyl amide compounds and uses related thereto

This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising 2-((benzo[d]imidazol-2-yl)thio)-N-phenylpropanamide derivatives, N-phenyl-2-

Host-directed inhibitors of myxoviruses: Synthesis and in vitro biochemical evaluation

Drugs targeted to viral proteins are highly vulnerable to the development of viral resistance. One little explored approach to the treatment of viral diseases is the development of agents that target host factors required for virus replication. Myxoviruses are predominantly associated with acute disease and, thus, ideally suited for this approach since the necessary treatment time is anticipated to be limited. High-throughput screening previously identified benzimidazole 22407448 with broad antiviral activity against different influenza virus and paramyxovirus strains. Hit to lead chemistry has generated 6p (JMN3-003) with potent antiviral activity against a panel of myxovirus family members exhibiting EC50 values in the low nanomolar range.