N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

Base Information

• Chemical Name: N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine
• CAS No.: 159217-68-2
• Molecular Formula: C₃₄H₃₆N₆O₆
• Molecular Weight: 624.696
• Mol file: 159217-68-2.mol

Synonyms:

Chemical Property of N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

There total 9 articles about N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N'-[9-((2R,3R,5S)-3-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine (869355-04-4) → N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine (159217-68-2)

Guidance literature:

In pyridine;

DOI:10.1080/07328319708006156

Reference yield:

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 2-Amino-9-{(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one → N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine (159217-68-2)

Guidance literature:

With methanol; In N,N-dimethyl-formamide; for 10h; Yield given; Ambient temperature;

DOI:10.1016/0040-4039(95)01447-P

Reference yield:

Acetic acid (3R,5S)-3-acetoxy-5-p-tolyloxymethyl-tetrahydro-furan-2-yl ester → N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine (159217-68-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) BSA, TMSOTf / 1.) DCE, 2.) TolH

2: 87 percent / NH₄OH / methanol / 48 h / 60 °C

3: 100 percent / adenosine deaminase, phosphate buffer / dimethylsulfoxide; H₂O

4: 92 percent / methanol

5: 87 percent / pyridine

With benzenesulfonamide; ammonium hydroxide; phosphate buffer; trimethylsilyl trifluoromethanesulfonate; adenosine deaminase; In pyridine; methanol; water; dimethyl sulfoxide;

DOI:10.1080/07328319708006156

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

4,4'-dimethoxytrityl chloride

N'-[9-((2R,3R,5S)-3-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine

2,6-bisacetamidopurine