C₂₈H₄₂N₈O₃

Base Information

• Chemical Name: C₂₈H₄₂N₈O₃
• CAS No.: 1440510-03-1
• Molecular Formula: C₂₈H₄₂N₈O₃
• Molecular Weight: 538.693
• Mol file: 1440510-03-1.mol

Synonyms:

Chemical Property of C₂₈H₄₂N₈O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₄₂N₈O₃

There total 15 articles about C₂₈H₄₂N₈O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H32O4Si (1440510-01-9) → C28H42N8O3 (1440510-03-1)

Guidance literature:

Multi-step reaction with 15 steps

1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C / Molecular sieve

2: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 1 h / 0 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: ammonia / methanol / 100 °C / Sealed tube

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

7: hydrazine / ethanol / 80 °C

8: sodium cyanoborohydride; acetic acid / methanol / 0 °C

9: methanol / 65 °C

10: lithium aluminium tetrahydride / tetrahydrofuran / -15 °C

11: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

12: hydrazine / ethanol / 80 °C

13: triethylamine / dichloromethane

14: hydrogenchloride / methanol

15: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; dipyridinium dichromate; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonia; hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; triphenylphosphine; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c3md00021d

Reference yield:

C30H33ClN4O3Si (1440510-02-0) → C28H42N8O3 (1440510-03-1)

Guidance literature:

Multi-step reaction with 12 steps

1: ammonia / methanol / 100 °C / Sealed tube

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

4: hydrazine / ethanol / 80 °C

5: sodium cyanoborohydride; acetic acid / methanol / 0 °C

6: methanol / 65 °C

7: lithium aluminium tetrahydride / tetrahydrofuran / -15 °C

8: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

9: hydrazine / ethanol / 80 °C

10: triethylamine / dichloromethane

11: hydrogenchloride / methanol

12: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonia; hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; triphenylphosphine; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1039/c3md00021d

Reference yield:

(3aR,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one (303963-92-0) → C28H42N8O3 (1440510-03-1)

Guidance literature:

Multi-step reaction with 14 steps

1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 1 h / 0 - 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3: ammonia / methanol / 100 °C / Sealed tube

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

6: hydrazine / ethanol / 80 °C

7: sodium cyanoborohydride; acetic acid / methanol / 0 °C

8: methanol / 65 °C

9: lithium aluminium tetrahydride / tetrahydrofuran / -15 °C

10: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

11: hydrazine / ethanol / 80 °C

12: triethylamine / dichloromethane

13: hydrogenchloride / methanol

14: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonia; hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; triphenylphosphine; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1039/c3md00021d

upstream raw materials:

C₂₇H₃₆SiO₄

C₂₅H₃₂O₄Si

(3aR,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one

(3aS,4S,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-ol