2-(4-chloro-3-methylphenoxy)-2-methylpropanoyl chloride

Base Information

• Chemical Name: 2-(4-chloro-3-methylphenoxy)-2-methylpropanoyl chloride
• CAS No.: 1160257-92-0
• Molecular Formula: C₁₁H₁₂Cl₂O₂
• Molecular Weight: 247.121
• Mol file: 1160257-92-0.mol

Synonyms:

Chemical Property of 2-(4-chloro-3-methylphenoxy)-2-methylpropanoyl chloride

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Chloro-3-methylphenoxy)-2-methylpropanoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chloro-3-methylphenoxy)-2-methylpropanoyl chloride

There total 2 articles about 2-(4-chloro-3-methylphenoxy)-2-methylpropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-(3-methyl-4-chlorophenoxy)isobutyric acid (62443-89-4) → 2-(4-Chloro-3-methyl-phenoxy)-2-methyl-propionyl chloride (1160257-92-0)

Guidance literature:

With thionyl chloride; for 0.5h; Heating;

Reference yield:

4-Chloro-3-methylphenol (59-50-7) → 2-(4-Chloro-3-methyl-phenoxy)-2-methyl-propionyl chloride (1160257-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / 0.5 h / 56 °C / Inert atmosphere

1.2: 3.5 h / 56 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; 1.1: |Bargellini Reaction / 1.2: |Bargellini Reaction;

DOI:10.1039/d1ob01395e

Reference yield:

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 2-(4-Chloro-3-methyl-phenoxy)-2-methyl-propionyl chloride (1160257-92-0) → 2-(4-chloro-3-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/d1ob01395e

upstream raw materials:

α-(3-methyl-4-chlorophenoxy)isobutyric acid

4-Chloro-3-methylphenol

Refernces

• 1、 Pekala, Elzbieta,Gajewczyk, Leonard,Marona, Henryk. "SYNTHESIS OF NEW N-ACYL DERIVATIVES OF DL-TRANS-1,2-AMINOCYCLOHEXANOL". . p. 339 - 342. Retrieved 2007/10/02.