(Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester

Base Information

• Chemical Name: (Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester
• CAS No.: 182627-54-9
• Molecular Formula: C₂₀H₂₁Cl₂FN₄O₄
• Molecular Weight: 471.316
• Mol file: 182627-54-9.mol

Synonyms:

Chemical Property of (Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester

There total 3 articles about (Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester (86483-52-5) + 4-Amino-1-(4-amino-butyl)-1H-pyrimidin-2-one (182627-50-5) → (Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester (182627-54-9)

Guidance literature:

In ethanol; dichloromethane; at 25 ℃; for 12h;

DOI:10.1016/0960-894X(96)00430-1

Reference yield:

4-Amino-1-(4-chloro-butyl)-1H-pyrimidin-2-one → (Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester (182627-54-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NaN₃, Bu₄NBr / acetonitrile / 25 °C / Heating

2: H₂ / Ra-Ni

3: 50 percent / CH₂Cl₂; ethanol / 12 h / 25 °C

With sodium azide; tetrabutylammomium bromide; hydrogen; Ra-Ni; In ethanol; dichloromethane; acetonitrile;

DOI:10.1016/0960-894X(96)00430-1

Reference yield:

ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate (86483-51-4) → (Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester (182627-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Ac₂O / 3 h / 130 °C

2: 50 percent / CH₂Cl₂; ethanol / 12 h / 25 °C

With acetic anhydride; In ethanol; dichloromethane;

DOI:10.1016/0960-894X(96)00430-1

upstream raw materials:

2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester

4-Amino-1-(4-amino-butyl)-1H-pyrimidin-2-one

ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate