Technology Process of Cbz-Ala-Ala-LeuP-(O)Phe-Ala-Ala-OMe
There total 10 articles about Cbz-Ala-Ala-LeuP-(O)Phe-Ala-Ala-OMe which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / 9 h / 110 °C
2: 95 percent / 2 N NaOH / methanol / 12 h / 21 °C
3: SOCl2 / CH2Cl2 / 4 h
4: Et3N / CH2Cl2 / 48 h
5: H2 / 10percent Pd/C / ethyl acetate / 3.5 h
6: 1) N-methylmorpholine, isobutylchloroformate / 1) EtOAc, -10 deg C, 2a) -10 deg C, 2b) r.t.
7: 1) isobutylene, trimethylsilyl bromide, 2) MeOH / 1) CH2Cl2, r.t.
With
4-methyl-morpholine; methanol; sodium hydroxide; thionyl chloride; trimethylsilyl bromide; hydrogen; triethylamine; isobutene; isobutyl chloroformate;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Et3N / CH2Cl2 / 48 h
2: H2 / 10percent Pd/C / ethyl acetate / 3.5 h
3: 1) N-methylmorpholine, isobutylchloroformate / 1) EtOAc, -10 deg C, 2a) -10 deg C, 2b) r.t.
4: 1) isobutylene, trimethylsilyl bromide, 2) MeOH / 1) CH2Cl2, r.t.
With
4-methyl-morpholine; methanol; trimethylsilyl bromide; hydrogen; triethylamine; isobutene; isobutyl chloroformate;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: SOCl2 / CH2Cl2 / 4 h
2: Et3N / CH2Cl2 / 48 h
3: H2 / 10percent Pd/C / ethyl acetate / 3.5 h
4: 1) N-methylmorpholine, isobutylchloroformate / 1) EtOAc, -10 deg C, 2a) -10 deg C, 2b) r.t.
5: 1) isobutylene, trimethylsilyl bromide, 2) MeOH / 1) CH2Cl2, r.t.
With
4-methyl-morpholine; methanol; thionyl chloride; trimethylsilyl bromide; hydrogen; triethylamine; isobutene; isobutyl chloroformate;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012
