128948-77-6

Upstream product

• 688047-48-5 ((R)-1-Benzylamino-3-methyl-but-2-enyl)-phosphonic acid bis-(2-nitro-benzyl) ester 
• 111865-48-6 benzyl-(3-methyl-but-2-enylidene)amine 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 88081-77-0 L-Leucine phosphonate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 128948-79-8 (R)-benzyl N-[1-(dimethoxyphosphoryl)-3-methylbutyl]carbamate 
• 90763-55-6 C₁₄H₂₁ClNO₄P 
• 128948-78-7 methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate 
• 128901-65-5 C₁₇H₂₇N₂O₅P 
• 90763-64-7 [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid 
• 128901-61-1 [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid ethyl ester 
• 90763-58-9 [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid tert-butyl ester 
• 208046-11-1 (S)-2-[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyloxy]-3-phenyl-propionic acid methyl ester 
• 110582-44-0 ((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-{[(S)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-methyl}-phosphinic acid 
• 110582-34-8 C₂₃H₃₉N₄O₅P 
• 90763-60-3 ((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-{[(S)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-methyl}-phosphinic acid methyl ester 
• 128923-36-4 Iva-Val-Val-Leu^P-(O)Phe-OMe 
• 128901-70-2 (S)-2-[Methoxy-((R)-3-methyl-1-{(S)-3-methyl-2-[(R)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-butyl)-phosphinoyloxy]-3-phenyl-propionic acid methyl ester 
• 128901-55-3 Cbz-Ala-Ala-Leu^P-(O)Phe-OMe 

Relevant academic research and scientific papers

A mild and convenient oxidation of H-phosphinic acids

A new mild and convenient method of oxidation of H-phosphinic to the corresponding phosphonic acids was developed. Conversion of H-phosphinic acids into trivalent trimethylsilyl esters using hexamethyldisilazane, followed by their oxidation with air and subsequent methanolysis allowed obtaining the final compounds in good to excellent yields. The methodology was proved to be particularly useful for N-benzyloxycarbonyl-α-aminophosphinic acids. The scope and limitations of the reaction were additionally tested using a variety of both free and protected amino- and hydroxyphosphinates as substrates.

Thiourea-Catalyzed Enantioselective Hydrophosphonylation of Imines: Practical Access to Enantiomerically Enriched α-Amino Phosphonic Acids

Chiral thiourea 1b catalyzes the highly enantioselective hydrophosphonylation of a wide range of N-benzyl imines. The hydrophosphonylation products are readily deprotected by hydrogenolysis, providing access to free α-amino phosphonic acids in highly enantioenriched form. Copyright

Potent Inhibition of Pepsin and Penicillopepsin by Phosphorus-Containing Peptide Analogues

Phosphinic and phosphonic acid peptide derivatives have been evaluated as inhibitors of the aspartic proteases pepsin and penicillopepsin.The most potent of those studied is isovaleryl-Val-Val-LeuP-(O)Phe-Ala-Ala-OMe (4) (LeuP repres