Trifluoro-acetic acid 3-{(3R,5S)-5-[(S)-1-amino-2-(3-fluoro-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-yl}-1,1-dimethyl-propyl ester

Base Information

• Chemical Name: Trifluoro-acetic acid 3-{(3R,5S)-5-[(S)-1-amino-2-(3-fluoro-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-yl}-1,1-dimethyl-propyl ester
• CAS No.: 1026721-04-9
• Molecular Formula: C₁₉H₂₃F₄NO₄
• Molecular Weight: 405.39
• Mol file: 1026721-04-9.mol

Synonyms:

Chemical Property of Trifluoro-acetic acid 3-{(3R,5S)-5-[(S)-1-amino-2-(3-fluoro-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-yl}-1,1-dimethyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-acetic acid 3-{(3R,5S)-5-[(S)-1-amino-2-(3-fluoro-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-yl}-1,1-dimethyl-propyl ester

There total 1 articles about Trifluoro-acetic acid 3-{(3R,5S)-5-[(S)-1-amino-2-(3-fluoro-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-yl}-1,1-dimethyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoroacetic acid (76-05-1) + tert-butyl (S)-2-(3-fluorophenyl)-1-((2S,4R)-tetrahydro-4-(3-methylbut-2-enyl)-5-oxofuran-2-yl)ethylcarbamate (379216-93-0) → Trifluoro-acetic acid 3-{(3R,5S)-5-[(S)-1-amino-2-(3-fluoro-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-yl}-1,1-dimethyl-propyl ester (1026721-04-9)

Guidance literature:

DOI:10.1016/j.bmcl.2004.02.022

Reference yield:

Trifluoro-acetic acid 3-{(3R,5S)-5-[(S)-1-amino-2-(3-fluoro-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-yl}-1,1-dimethyl-propyl ester (1026721-04-9) → CP 481715 (212790-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / CH₂Cl₂

2: NH₃; AcOH / dioxane / Heating

With TEA; ammonia; acetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2004.02.022

Reference yield:

quinoxaline-2-carboxylic acid chloride (54745-92-5) + Trifluoro-acetic acid 3-{(3R,5S)-5-[(S)-1-amino-2-(3-fluoro-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-yl}-1,1-dimethyl-propyl ester (1026721-04-9) → trifluoro-acetic acid 3-(5-{2-(3-fluoro-phenyl)-1-[(quinoxaline-2-carbonyl)-amino]-ethyl}-2-oxo-tetrahydrofuran-3-yl)-1,1-dimethyl-propyl ester (624736-64-7)

Guidance literature:

With TEA; In dichloromethane;

DOI:10.1016/j.bmcl.2004.02.022

upstream raw materials:

trifluoroacetic acid

tert-butyl (S)-2-(3-fluorophenyl)-1-((2S,4R)-tetrahydro-4-(3-methylbut-2-enyl)-5-oxofuran-2-yl)ethylcarbamate

Downstream raw materials:

trifluoro-acetic acid 3-(5-{2-(3-fluoro-phenyl)-1-[(quinoxaline-2-carbonyl)-amino]-ethyl}-2-oxo-tetrahydrofuran-3-yl)-1,1-dimethyl-propyl ester

CP 481715