(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

Base Information

Chemical Name:(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one
CAS No.:129144-93-0
Molecular Formula:C₄₂H₆₂O₅Si₂
Molecular Weight:703.122
Hs Code.:

(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

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Chemical Property of (2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of (2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

There total 13 articles about (2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28127-64-2
methyl (2E)-2-(hydroxymethyl)-2-butenoate

: 129144-93-0,147058-96-6,147058-97-7
(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

Guidance literature:: Multi-step reaction with 11 steps

1: 98 percent / imidazole / dimethylformamide / 23 °C

2: 94 percent / DIBAL-H / diethyl ether / -50 - -30 °C

3: 86 percent / MnO₂ / CH₂Cl₂ / 23 °C

4: 90 percent / CH₂Cl₂ / Heating

5: 96 percent / DIBAL-H / diethyl ether / -50 °C

6: 98 percent / MnO₂ / CH₂Cl₂ / 23 °C

7: 89 percent / LiN(TMS)2 / tetrahydrofuran / 0 °C

8: 73 percent / BHT / trichloroethene / 16 h / 135 °C

9: 97 percent / DIBAL-H / CH₂Cl₂ / -78 - -30 °C

10: 89 percent / imidazole / dimethylformamide / 23 °C

11: 1) DMSO, (COCl)2, 2) Et₃N / 1) -78 deg C, CH₂Cl₂

With 1H-imidazole; manganese(IV) oxide; oxalyl dichloride; 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; Trichloroethylene; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)70684-8

Reference yield:

: 146983-30-4
4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E),4(Z)-hexadienol

: 129144-93-0,147058-96-6,147058-97-7
(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / MnO₂ / CH₂Cl₂ / 23 °C

2: 89 percent / LiN(TMS)2 / tetrahydrofuran / 0 °C

3: 73 percent / BHT / trichloroethene / 16 h / 135 °C

4: 97 percent / DIBAL-H / CH₂Cl₂ / -78 - -30 °C

5: 89 percent / imidazole / dimethylformamide / 23 °C

6: 1) DMSO, (COCl)2, 2) Et₃N / 1) -78 deg C, CH₂Cl₂

With 1H-imidazole; manganese(IV) oxide; oxalyl dichloride; 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; Trichloroethylene; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)70684-8

Reference yield:

: 146983-23-5
4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E),4(Z)-hexadienal

: 129144-93-0,147058-96-6,147058-97-7
(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / LiN(TMS)2 / tetrahydrofuran / 0 °C

2: 73 percent / BHT / trichloroethene / 16 h / 135 °C

3: 97 percent / DIBAL-H / CH₂Cl₂ / -78 - -30 °C

4: 89 percent / imidazole / dimethylformamide / 23 °C

5: 1) DMSO, (COCl)2, 2) Et₃N / 1) -78 deg C, CH₂Cl₂

With 1H-imidazole; oxalyl dichloride; 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; Trichloroethylene; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)70684-8