(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol

Base Information

Chemical Name:(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol
CAS No.:146983-31-5
Molecular Formula:C₄₂H₆₄O₅Si₂
Molecular Weight:705.138
Hs Code.:

(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol

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Chemical Property of (2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol

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Technology Process of (2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol

There total 9 articles about (2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 129144-92-9,129261-11-6,147058-95-5,147059-02-7
(2R,5S,6R,9R)-8-(tert-Butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-6-((E)-3-hydroxy-2-methyl-propenyl)-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 146983-31-5,147059-03-8,147059-04-9,147059-05-0
(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 23 ℃;
DOI:10.1016/S0040-4039(00)70684-8

Reference yield:

: 129144-88-3
2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E)-butenal

: 146983-31-5,147059-03-8,147059-04-9,147059-05-0
(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / CH₂Cl₂ / Heating

2: 96 percent / DIBAL-H / diethyl ether / -50 °C

3: 98 percent / MnO₂ / CH₂Cl₂ / 23 °C

4: 89 percent / LiN(TMS)2 / tetrahydrofuran / 0 °C

5: 73 percent / BHT / trichloroethene / 16 h / 135 °C

6: 97 percent / DIBAL-H / CH₂Cl₂ / -78 - -30 °C

7: 89 percent / imidazole / dimethylformamide / 23 °C

With 1H-imidazole; manganese(IV) oxide; 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; Trichloroethylene; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)70684-8

Reference yield:

: 146983-21-3
2-<<(tert-butyldiphenylsilyl)oxy>methyl>-2(Z)-butenol

: 146983-31-5,147059-03-8,147059-04-9,147059-05-0
(2R,5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-cyclohexyl-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / MnO₂ / CH₂Cl₂ / 23 °C

2: 90 percent / CH₂Cl₂ / Heating

3: 96 percent / DIBAL-H / diethyl ether / -50 °C

4: 98 percent / MnO₂ / CH₂Cl₂ / 23 °C

5: 89 percent / LiN(TMS)2 / tetrahydrofuran / 0 °C

6: 73 percent / BHT / trichloroethene / 16 h / 135 °C

7: 97 percent / DIBAL-H / CH₂Cl₂ / -78 - -30 °C

8: 89 percent / imidazole / dimethylformamide / 23 °C

With 1H-imidazole; manganese(IV) oxide; 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; Trichloroethylene; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)70684-8