ethyl 6-methoxy-2-methylnicotinate

Base Information

• Chemical Name: ethyl 6-methoxy-2-methylnicotinate
• CAS No.: 173261-76-2
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 173261-76-2.mol

Synonyms:

Chemical Property of ethyl 6-methoxy-2-methylnicotinate

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Ethyl6-methoxy-2-methylnicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 6-methoxy-2-methylnicotinate

There total 7 articles about ethyl 6-methoxy-2-methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (3424-43-9) + methyl iodide (74-88-4) → ethyl 6-methoxy-2-methylnicotinate (173261-76-2)

Guidance literature:

With silver carbonate; at 50 ℃; for 16h;

DOI:10.1016/j.bmcl.2018.01.058

Reference yield:

2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester (4027-39-8) → ethyl 6-methoxy-2-methylnicotinate (173261-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent Pd/C

2: Ag₂CO₃ / tetrahydrofuran; benzene

With silver carbonate; 30% palladium on charcoal catalyst; In tetrahydrofuran; benzene; 1: Catalytic oxidation / 2: Etherification;

Reference yield:

ethyl 2-(2-cyanoethyl)-3-oxobutanoate (10444-33-4) → ethyl 6-methoxy-2-methylnicotinate (173261-76-2)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / CHCl₃

2: 30 percent Pd/C

3: Ag₂CO₃ / tetrahydrofuran; benzene

With hydrogenchloride; silver carbonate; 30% palladium on charcoal catalyst; In tetrahydrofuran; chloroform; benzene; 1: Cyclization / 2: Catalytic oxidation / 3: Etherification;

upstream raw materials:

ethyl 6-hydroxy-2-methylnicotinate

methyl iodide

ethyl 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester

Downstream raw materials:

3-Hydroxymethyl-6-methoxy-2-methylpyridin

6-methoxy-2-methylnicotinic acid