4027-39-8

Usage

Structure

Consists of a pyridine ring and a carboxylic acid group

Usage

Commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Potential Applications

Field of medicine and drug development due to its structural properties and reactivity

Safety Precautions

Important to handle with care as it may have hazardous properties

Storage

Should be used and stored in accordance with proper safety procedures

Upstream product

• 10444-33-4 ethyl 2-(2-cyanoethyl)-3-oxobutanoate 
• 140-88-5 ethyl acrylate 
• 141-97-9 ethyl acetoacetate 
• 79-10-7 acrylic acid 
• 1501-06-0 diethyl 2-acetylglutarate 
• 64-17-5 ethanol 
• 7664-41-7 ammonia 

Downstream Products

• 3424-43-9 ethyl 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 3279-76-3 6-hydroxy-2-methylpyridine 
• 66909-37-3 6-hydroxy-2-methyl-nicotinic acid 
• 31163-12-9 ethyl 6-chloro-2-methylnicotinate 
• 41598-77-0 5-bromo-6-hydroxy-2-methyl-nicotinic acid ethyl ester 
• 32383-10-1 3-Hydroxymethyl-6-methoxy-2-methylpyridin 
• 173261-76-2 ethyl 6-methoxy-2-methylnicotinate 
• 3424-43-9 ethyl 6-hydroxy-2-methylnicotinate 

Relevant academic research and scientific papers

One-pot synthesis of 3,4-dihydropyridin-2-ones via tandem reaction of Blaise reaction intermediate and acrylic ester

An efficient method for the synthesis 3,4-dihydropyridin-2-ones has been developed via tandem one-pot Michael-type addition and cyclization of the Blaise reaction intermediate and acrylic ester. A series of readily available nitriles, bromoacetic esters and acrylic esters have been employed to examine the scope of substrates for this method.

One-pot synthesis of 3,4-dihydropyridin-2-one via michael addition of in situ-generated enaminones

Herein we have reported a facile solvent-, catalyst-, and aldehyde-free, one-pot synthesis of 3,4-dihydropyridin-2-one from 1,3-diones using simple and mild reaction conditions. The substrate scope has been also extended to β-ketoesters.

Synthesis of 2,3-disubstituted 4-pyridone from a β-aminocarboxylate derivative and acetoacetate

The reaction of diethyl aminomethylenemalonate with ethyl acetoacetate proceeded, when catalyzed by anhydrous hydrogen chloride, toward a respectively substituted α- instead of γ-pyridone derivative formation, contrary to the literature report. Additionally, it was found that the amine used as a starting component in this reaction showed a great tendency to autocondensation under the influence of anhydrous hydrogen chloride to yield 5-ethoxycarbonyl-2- pyridone. The most convenient method to prepare 4-pyridone 2,3-disubstituted derivative appeared to be a three-step synthesis, starting from a chain enamine formation, which was subjected to cyclization, followed by oxidation of the last intermediate. The usefulness of the stepwise synthesis was demonstrated on the 3-ethoxycarbonyl-2-methyl-4-pyridone preparation as an example. Copyright Taylor & Francis, Inc.

Studies on Molecular Modification of Novel Constituents of Chinese Medicinal Plants

Several novel active principles have been isolated and identified from Chinese herbs in the Shanghai Institute of Materia Medica. The syntheses of huperzine A and edulinine are described here. Numerous new compounds have been synthesized by modification of the structures of the natural constituents. Pharmacological examinations showed that some of such compounds were biologically active.