10444-33-4Relevant articles and documents
Novel enzymatic reduction of α-amido- and α-cyanoalkyl-β-keto esters catalyzed by ketoreductases
Giannopoulos, Vasileios,Myrtollari, Kamela,Smonou, Ioulia,Tyrikos-Ergas, Theodore
, (2020)
An enzymatic approach for the asymmetric reduction of α-amido- and α-cyanoalkyl-β-keto esters has been developed. We have shown that NADPH-dependent ketoreductases can catalyze these transformations with excellent activity and high stereoselectivity, leading to optically pure β-hydroxy-α-amido esters as well as optically pure β-hydroxy-α-cyanoalkyl esters. With this method tert-butyl 2-acetamido-3-hydroxy-4-methylpentanoate, a valuable chiral intermediate for the synthesis of lactacystin, was obtained in high yield and excellent anti-diastereoselectivity. The ketoreductase catalyzed reduction of α-cyanomethyl- and α-cyanoethyl-β-keto esters to form the corresponding optically pure β-hydroxy esters, which are chiral intermediates for the synthesis of optically pure α-substituted γ-butyro and δ-valerolactams, was accomplished in high yield and high stereoselectivity leading to one stereoisomer out of four (>99 % de, >99 % ee, >99 % conversion).
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Bergmann,Corett
, (1958)
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IRON PENTACARBONYL HALOGEN INITIATED REACTION OF ETHYL ACETOACETATE AND ACETYLACETONE WITH ACRYLIC MONOMERS
Amriev, R.A.,Velichko, F.K.,Abdulkina, Z.A.,Freidlina, R.Kh.
, p. 2335 - 2339 (1984)
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2,3-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 31-32, (2010/05/13)
The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin recepto