(S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride

Base Information

• Chemical Name: (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride
• CAS No.: 2306254-23-7
• Molecular Formula: C₁₃H₁₈N₂*ClH
• Molecular Weight: 238.76
• Mol file: 2306254-23-7.mol

Synonyms:

Chemical Property of (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride

There total 10 articles about (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl (1S)-1-((tert-butylsulfinyl)amino)-1,3-dihydrospiro[indene-2,4’-piperidine]-1’-carboxylate (2245085-40-7) → (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride (2306254-23-7)

Guidance literature:

With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 99.0%

tert-butyl (S)-1-(((R)-tert-butylsulfinyl)amino)-1,3-dihydrospiro[indene-2,4’-piperidine]-1‘-carboxylate (2245085-40-7) → (S)-1,3-dihydrospiro[indene-2,4′-piperidine]-1-amine dihydrochloride (2306254-23-7)

Guidance literature:

With hydrogenchloride; In methanol; at 20 - 60 ℃; for 19h;

Reference yield:

tert-butyl 1-oxo-1,3-dihydrospiro[indene-2,4’-piperidine]-1’-carboxylate (1228079-29-5) → (S)-1,3-dihydrospiro[indene-2,4′-piperidine]-1-amine dihydrochloride (2306254-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 16 h / 90 °C

1.2: 0.5 h / 0 °C

2.1: hydrogenchloride / methanol / 19 h / 20 - 60 °C

With hydrogenchloride; titanium(IV) tetraethanolate; In 2-methyltetrahydrofuran; methanol;

upstream raw materials:

inden-1-one

tert-butyl 1-oxo-1,3-dihydrospiro[indene-2,4’-piperidine]-1’-carboxylate

tert-butyl (S)-1-(((R)-tert-butylsulfinyl)amino)-1,3-dihydrospiro[indene-2,4’-piperidine]-1‘-carboxylate

4-benzyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Refernces

• 1、 -. "NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS". . . Retrieved 2020/05/12.
• 2、 -. "PYRIMIDINONE DERIVATIVES AS SHP2 ANTAGONISTS". Page/Page column 89; 115; 118. . Retrieved 2020/10/21.