2245085-40-7

Basic information

• Product Name: tert-butyl (S)-1-((S)-tert-butylsulfinylamino)-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate
• CAS NO: 2245085-40-7
• Molecular Weight: 406.59
• Mol File: 2245085-40-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: tert-butyl (S)-1-((S)-tert-butylsulfinylamino)-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (S)-1-((S)-tert-butylsulfinylamino)-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate(2245085-40-7)
• EPA Substance Registry System: tert-butyl (S)-1-((S)-tert-butylsulfinylamino)-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate(2245085-40-7)

Safety Data

• Hazardous Substances Data: 2245085-40-7(Hazardous Substances Data)

Usage

General Description

Tert-butyl (S)-1-((S)-tert-butylsulfinylamino)-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate is a complex chemical compound. It contains a tert-butyl group attached to a sulfinylamino group, which is further linked to a spiro[indene-2,4'-piperidine]-1'-carboxylate structure. This molecule is chiral, with two asymmetric carbon atoms, giving rise to different stereoisomers. The presence of the tert-butylsulfinylamino and spiro[indene-2,4'-piperidine] moieties may indicate potential pharmaceutical or biological activity, as these functional groups are commonly found in drug molecules. The compound's specific properties and potential applications would need to be further investigated through synthesis and testing.

Upstream product

• 1228079-29-5 tert-butyl 1-oxo-1,3-dihydrospiro[indene-2,4’-piperidine]-1’-carboxylate 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 
• 83-33-0 inden-1-one 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 136080-25-6 spiro[indene-2,4’-piperidin]-1(3H)-one 
• 100-39-0 benzyl bromide 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 167263-10-7 4-benzyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 

Downstream Products

• 2245085-41-8 (R)-N-((S)-1,3-dihydrospiro[indene-2,4’-piperidin]-1-yl)-2-methylpropane-2-sulfinamide 
• 2245085-41-8 (S)-N-((S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-yl)-2-methylpropane-2-sulfinamide 
• 2306254-23-7 (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride 
• 2306254-23-7 (S)-1,3-dihydrospiro[indene-2,4′-piperidine]-1-amine dihydrochloride 

Relevant articles and documents

SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF

Provided herein are compounds of Formula (I), methods of using the compounds as SHP2 inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating SHP2-mediated diseases.

SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF

Provided are compounds of Formula (I), methods of using the compounds as SHP2 inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating SHP2-mediated diseases.

REGULATOR OF NITROGEN-CONTAINING HETEROAROMATIC DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a regulator of nitrogen-containing heteroaromatic derivatives, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer, wherein the definition of each substituent in the general formula (I) is the same as that in the description.