1-Tert-butyl 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-Tert-butyl 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate
CAS No.:167263-10-7
Molecular Formula:C20H29NO4
Molecular Weight:347.455
Hs Code.:
European Community (EC) Number:693-892-1
DSSTox Substance ID:DTXSID70584847
Wikidata:Q82476585
Mol file:167263-10-7.mol

Synonyms:167263-10-7;1-tert-butyl 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate;Ethyl N-Boc-4-benzylpiperidine-4-carboxylate;1-O-tert-butyl 4-O-ethyl 4-benzylpiperidine-1,4-dicarboxylate;1-tert-Butyl4-ethyl4-benzylpiperidine-1,4-dicarboxylate;SCHEMBL965515;DTXSID70584847;CWWGEJKQPHMAOY-UHFFFAOYSA-N;MFCD09038429;CS-0336913;Ethyl N-Boc-4-benzylpiperidine-4-carboxylate, 96%;J-010348;1-t-Butyl 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate;1-(Tert-butyl) 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate;4-Benzyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester;4-benzylpiperidine-1,4-dicarboxylic acid tert-butyl ester ethyl ester;N-tert-butyloxycarbonyl-4-benzylpiperidine-4-carboxylic acid ethyl ester

Suppliers and Price of 1-Tert-butyl 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL N-BOC-4-BENZYLPIPERIDINE-4-CARBOXYLATE 95.00%
1G
$ 759.79

Crysdot
1-tert-Butyl4-ethyl4-benzylpiperidine-1,4-dicarboxylate 97%
1g
$ 490.00

Total 6 raw suppliers

Chemical Property of 1-Tert-butyl 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate

Chemical Property:

Refractive Index:n20/D 1.5028
Flash Point:110oC
PSA：55.84000
LogP:3.74740
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:347.20965841
Heavy Atom Count:25
Complexity:455

Purity/Quality:

97% ^*data from raw suppliers

ETHYL N-BOC-4-BENZYLPIPERIDINE-4-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1(CCN(CC1)C(=O)OC(C)(C)C)CC2=CC=CC=C2

Technology Process of 1-Tert-butyl 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate

There total 4 articles about 1-Tert-butyl 4-ethyl 4-benzylpiperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 167263-10-7
4-benzyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:

Reference yield:

: 100-39-0
benzyl bromide

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 167263-10-7
4-benzyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; at -78 ℃; for 0.0833333h;

benzyl bromide; In tetrahydrofuran; hexanes; at 20 ℃;

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 167263-10-7
4-benzyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.17 h / 0 - 20 °C

1.2: 14 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1.25 h / -75 - -35 °C / Inert atmosphere

2.2: -75 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;