Technology Process of [3-fluoro-2-(pinacolatoboron)phenyl]BiCl2
There total 3 articles about [3-fluoro-2-(pinacolatoboron)phenyl]BiCl2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
isopropylmagnesium chloride*LiCl;
In
tetrahydrofuran;
under Ar; B compd. dissolved in THF; cooled to -78°C (dry ice-EtOH bath); i-PrMgCl*LiCl (1 equiv.) in THF added; soln. of BiCl3 (0.8 equiv.) in THF (-78°C) added; rinsed with THF; stirred for 12 h; warmed to room temp.; poured into satd. aq. NH4Cl; extd. with EtOAc; org. layer washed with brine; dried (Na2SO4); filtered; concd. in vac.; recrystd. from CH2Cl2; elem. anal.;
DOI:10.1021/om7009792
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene
2: isopropylmagnesium chloride*LiCl / tetrahydrofuran
With
isopropylmagnesium chloride*LiCl;
In
tetrahydrofuran; toluene;
DOI:10.1021/om7009792
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene
2: isopropylmagnesium chloride*LiCl / tetrahydrofuran
With
isopropylmagnesium chloride*LiCl;
In
tetrahydrofuran; toluene;
DOI:10.1021/om7009792
