6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

Base Information

• Chemical Name: 6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
• CAS No.: 1280218-08-7
• Molecular Formula: C₂₁H₂₂F₂N₄O₅S
• Molecular Weight: 480.492
• Mol file: 1280218-08-7.mol

Synonyms:

Chemical Property of 6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

There total 6 articles about 6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminotetrahydropyran (38041-19-9) + 6-(2,4-difluorophenoxy)-2-methanesulfonyl-8-(2-methanesulfonylethyl)-8H-pyrido[2,3-d]pyrimidin-7-one (1313610-16-0) → 6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-08-7)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 68 ℃; for 2.5h;

DOI:10.1021/jm101423y

Reference yield:

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde (770-31-0) → 6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-08-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 120 °C

2: tributylphosphine; diethylazodicarboxylate / N,N-dimethyl-formamide / 0 - 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

4: sodium carbonate / tetrahydrofuran / 2.5 h / 68 °C

With tributylphosphine; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; diethylazodicarboxylate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm101423y

Reference yield:

6-(2,4-difluorophenoxy)-2-methylsulfanyl-8-(2-methylsulfanylethyl)-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-33-8) → 6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2: sodium carbonate / tetrahydrofuran / 2.5 h / 68 °C

With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm101423y

upstream raw materials:

4-aminotetrahydropyran

6-(2,4-difluorophenoxy)-2-methanesulfonyl-8-(2-methanesulfonylethyl)-8H-pyrido[2,3-d]pyrimidin-7-one

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

6-(2,4-difluorophenoxy)-2-methylsulfanyl-8-(2-methylsulfanylethyl)-8H-pyrido[2,3-d]pyrimidin-7-one