tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-({[(2-methoxyethyl)sulfonyl]amino}methyl)-1,4-oxazepane-4-carboxylate

Base Information

• Chemical Name: tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-({[(2-methoxyethyl)sulfonyl]amino}methyl)-1,4-oxazepane-4-carboxylate
• CAS No.: 1372189-16-6
• Molecular Formula: C₂₀H₃₀Cl₂N₂O₆S
• Molecular Weight: 497.44
• Mol file: 1372189-16-6.mol

Synonyms:

Chemical Property of tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-({[(2-methoxyethyl)sulfonyl]amino}methyl)-1,4-oxazepane-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-({[(2-methoxyethyl)sulfonyl]amino}methyl)-1,4-oxazepane-4-carboxylate

There total 13 articles about tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-({[(2-methoxyethyl)sulfonyl]amino}methyl)-1,4-oxazepane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(ethenylsulfonyl)amino]methyl}-1,4-oxazepane-4-carboxylate (1372190-05-0) + sodium methylate (124-41-4) → tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-({[(2-methoxyethyl)sulfonyl]amino}methyl)-1,4-oxazepane-4-carboxylate (1372189-16-6)

Guidance literature:

at 60 ℃; for 4h;

Reference yield:

tert-butyl (6S,7R)-6-(azidomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (1372186-95-2) → tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-({[(2-methoxyethyl)sulfonyl]amino}methyl)-1,4-oxazepane-4-carboxylate (1372189-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

2: triethylamine / tetrahydrofuran / 0 - 35 °C

3: 4 h / 60 °C

With water; triethylamine; triphenylphosphine; In tetrahydrofuran; 1: Staudinger Reaction;

Reference yield:

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate (1372189-39-3) → tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-({[(2-methoxyethyl)sulfonyl]amino}methyl)-1,4-oxazepane-4-carboxylate (1372189-16-6)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

2: sodium azide / N,N-dimethyl-formamide / 70 °C

3: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

4: triethylamine / tetrahydrofuran / 0 - 35 °C

5: 4 h / 60 °C

With sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Staudinger Reaction;

upstream raw materials:

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate

tert-butyl (6S,7R)-6-(azidomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

methanol