p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>-1-carba-1-dethia-3-cephem-4-carboxylate

Base Information

• Chemical Name: p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>-1-carba-1-dethia-3-cephem-4-carboxylate
• CAS No.: 127132-79-0
• Molecular Formula: C₂₂H₁₈F₃N₃O₉S₂
• Molecular Weight: 589.527
• Mol file: 127132-79-0.mol

Synonyms:

Chemical Property of p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>-1-carba-1-dethia-3-cephem-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>-1-carba-1-dethia-3-cephem-4-carboxylate

There total 1 articles about p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>-1-carba-1-dethia-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thienylacetic acid chloride (39098-97-0) + p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-{[(trifluoromethyl)sulfonyl]oxy}-1-carba-1-dethia-3-cephem-4-carboxylate (108493-71-6) → p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>-1-carba-1-dethia-3-cephem-4-carboxylate (127132-79-0)

Guidance literature:

With 2,6-dimethylpyridine; phosphorus pentachloride; Yield given. Multistep reaction; 1.) CH₂Cl₂, 23 deg C, 3 h, 2.) 23 deg C, 16 h;

DOI:10.1021/jm00168a019

Reference yield: 27.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>-1-carba-1-dethia-3-cephem-4-carboxylate (127132-79-0) → p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-carbomethoxy-1-carba-1-dethia-3-cephem-4-carboxylate (127132-80-3)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); triethylamine; lithium chloride; In N,N-dimethyl-formamide; for 3.5h;

DOI:10.1021/jm00168a019

Reference yield: 9.0%

carbon monoxide (201230-82-2) + p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>-1-carba-1-dethia-3-cephem-4-carboxylate (127132-79-0) → p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-carboxy-1-carba-1-dethia-3-cephem-4-carboxylate (127132-81-4)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); formic acid; triethylamine; In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/jm00168a019

upstream raw materials:

2-thienylacetic acid chloride

p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-{[(trifluoromethyl)sulfonyl]oxy}-1-carba-1-dethia-3-cephem-4-carboxylate

Downstream raw materials:

p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-carbomethoxy-1-carba-1-dethia-3-cephem-4-carboxylate

p-nitrobenzyl (7S,6R)-7-(2-thienylacetamido)-3-carboxy-1-carba-1-dethia-3-cephem-4-carboxylate