6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol

Base Information

Chemical Name:6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol
CAS No.:201860-67-5
Molecular Formula:C₅₆H₇₇Br₂F₃O₁₂Si₂
Molecular Weight:1215.19
Hs Code.:

6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol

There total 7 articles about 6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.7%

: 15356-62-4
L-menthoxyacetyl chloride

: 6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-myo-inositol

: 201860-69-7
6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-L-myo-inositol

: 201860-67-5
6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol

Guidance literature:: With pyridine; 1H-tetrazole; dmap; In acetonitrile; at 20 ℃; for 0.75h;
DOI:10.1039/b007267m

Reference yield: 40.7%

: 15356-62-4
L-menthoxyacetyl chloride

: (1R,2R,3R,4R,4aS,9aS)-4-[2,7-Dibromo-9-(3-trifluoromethyl-phenyl)-9H-xanthen-9-yloxy]-6,6,8,8-tetraisopropyl-2-(4-methoxy-tetrahydro-pyran-4-yloxy)-hexahydro-5,7,9-trioxa-6,8-disila-benzocycloheptene-1,3-diol

: 201860-69-7
6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-L-myo-inositol

: 201860-67-5
6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol

Guidance literature:: With pyridine; 1H-tetrazole; dmap; In acetonitrile; for 0.75h; Ambient temperature;
DOI:10.1016/S0960-894X(97)10166-4

Reference yield:

: 17327-22-9
4-methoxy-2,6-dihydropyran

: 201860-67-5
6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol

Guidance literature:: Multi-step reaction with 5 steps

1: 44.73 g / Ph₃P*HBr / CH₂Cl₂ / 40 h / 20 °C

2: 18.27 g / NaOMe / methanol; tetrahydrofuran / 0.5 h / 20 °C

3: 62.8 percent / imidazole; Et₃N / hexamethylphosphoric acid triamide / 60 h / 20 °C

4: 73 percent / pyridine / acetonitrile / 1.33 h / 20 °C

5: 40.5 percent / 1H-tetraole; DMAP; pyridine / acetonitrile / 0.75 h / 20 °C

With pyridine; 1H-imidazole; 1H-tetrazole; dmap; sodium methylate; triphenylphosphine hydrobromide; triethylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; acetonitrile;
DOI:10.1039/b007267m