(3,5-dichloro-4-fluorophenyl)boronic acid

Base Information

• Chemical Name: (3,5-dichloro-4-fluorophenyl)boronic acid
• CAS No.: 1646614-31-4
• Molecular Formula: C₆H₄BCl₂FO₂
• Molecular Weight: 208.812
• Hs Code.: 2931900090
• Mol file: 1646614-31-4.mol

Synonyms:

Chemical Property of (3,5-dichloro-4-fluorophenyl)boronic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

3,5-Dichloro-4-fluorophenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,5-dichloro-4-fluorophenyl)boronic acid

There total 1 articles about (3,5-dichloro-4-fluorophenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 5-bromo-1,3-dichloro-2-fluorobenzene (17318-08-0) → (3,5-dichloro-4-fluorophenyl)boronic acid (1646614-31-4)

Guidance literature:

5-bromo-1,3-dichloro-2-fluorobenzene; With magnesium; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

Trimethyl borate; In tetrahydrofuran; at -40 ℃; for 4h;

Reference yield: 66.0%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + (3,5-dichloro-4-fluorophenyl)boronic acid (1646614-31-4) → 1,3-dichloro-2-fluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (928783-84-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In toluene; at 80 ℃; for 9h; Inert atmosphere;

Reference yield:

(3,5-dichloro-4-fluorophenyl)boronic acid (1646614-31-4) → 4-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid (1332698-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / toluene / 9 h / 80 °C / Inert atmosphere

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 40 °C

2.2: 20 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 2 h

With bis-triphenylphosphine-palladium(II) chloride; N-chloro-succinimide; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

upstream raw materials:

Trimethyl borate

5-bromo-1,3-dichloro-2-fluorobenzene

Downstream raw materials:

4-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

1,3-dichloro-2-fluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

Refernces

• 1、 -. "A substituted benzamide isoxazoline derivative or a salt thereof as a pesticidally acceptable salt. Composition and use thereof". Paragraph 0101-0104. . Retrieved 2021/10/30.