2-(Methoxymethyl)-3,4,5-triphenylfuran

Base Information

• Chemical Name: 2-(Methoxymethyl)-3,4,5-triphenylfuran
• CAS No.: 106241-00-3
• Molecular Formula: C24H20O2
• Molecular Weight: 340.422
• DSSTox Substance ID: DTXSID10544324
• Nikkaji Number: J2.188.447B
• Wikidata: Q82421408
• Mol file: 106241-00-3.mol

Synonyms:106241-00-3;2-(Methoxymethyl)-3,4,5-triphenylfuran;DTXSID10544324

Chemical Property of 2-(Methoxymethyl)-3,4,5-triphenylfuran

Chemical Property:

• XLogP3: 5.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 340.146329876
• Heavy Atom Count: 26
• Complexity: 404

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=C(C(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 2-(Methoxymethyl)-3,4,5-triphenylfuran

There total 3 articles about 2-(Methoxymethyl)-3,4,5-triphenylfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methanol (67-56-1) + (Z)-3,4,5-triphenyl-3-pentene-2,5-dione (79919-04-3) → methoxymethyl-2 triphenyl-3,4,5 furanne (106241-00-3)

Guidance literature:

toluene-4-sulfonic acid; for 48h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87353-1

Reference yield: 71.0%

dimethoxy-2,5 methyl-2 triphenyl-3,4,5 dihydro-2,5 furanne (106240-96-4) → triphenyl-3,4,5 furannecarbaldehyde-2 (106241-01-4) + methoxymethyl-2 triphenyl-3,4,5 furanne (106241-00-3) + methylene-2,2' bis(triphenyl-3,4,5 furanne) (106241-02-5)

Guidance literature:

toluene-4-sulfonic acid; In benzene; for 48h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87353-1

Reference yield: 66.0%

2-methoxyacetonitrile (1738-36-9) + benzaldehyde (100-52-7) + diphenyl acetylene (501-65-5) → methoxymethyl-2 triphenyl-3,4,5 furanne (106241-00-3)

Guidance literature:

diphenyl acetylene; With titanium(IV) isopropylate; isopropylmagnesium chloride; In diethyl ether; at -78 - -50 ℃;

2-methoxyacetonitrile; In diethyl ether; at -50 ℃; for 3h;

benzaldehyde; In diethyl ether; at -50 - 20 ℃;

DOI:10.1021/ja0502730

upstream raw materials:

methanol

(Z)-3,4,5-triphenyl-3-pentene-2,5-dione

dimethoxy-2,5 methyl-2 triphenyl-3,4,5 dihydro-2,5 furanne

2-methoxyacetonitrile