(5RS)-5r-hydroxy-6t-[(1RS)-3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: (5RS)-5r-hydroxy-6t-[(1RS)-3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester
• CAS No.: 61377-97-7
• Molecular Formula: C₂₄H₂₈N₂O₆S₂
• Molecular Weight: 504.628

Synonyms:

Chemical Property of (5RS)-5r-hydroxy-6t-[(1RS)-3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of (5RS)-5r-hydroxy-6t-[(1RS)-3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester

There total 31 articles about (5RS)-5r-hydroxy-6t-[(1RS)-3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

4-carbo-t-butoxyoxepin (33279-99-1) + (1R,3R,5R)-3-(4-Methoxy-phenyl)-6-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione (61377-96-6,79298-60-5,79298-61-6,79298-67-2,98574-83-5) → (5S,6S)-5-Hydroxy-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester (61377-97-7,79298-62-7,79298-68-3,79298-69-4,79298-70-7,79298-74-1,79299-12-0) + (5R,6R)-5-Hydroxy-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester (61377-97-7,79298-62-7,79298-68-3,79298-69-4,79298-70-7,79298-74-1,79299-12-0)

Guidance literature:

N-benzyl-trimethylammonium hydroxide; In dimethyl sulfoxide; for 30h; Ambient temperature;

DOI:10.1016/S0040-4020(01)97960-8

Reference yield: 59.0%

4-carbo-t-butoxyoxepin (33279-99-1) + (1R,3R,5R)-3-(4-Methoxy-phenyl)-6-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione (61377-96-6,79298-60-5,79298-61-6,79298-67-2,98574-83-5) → (5S,6S)-5-Hydroxy-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester (61377-97-7,79298-62-7,79298-68-3,79298-69-4,79298-70-7,79298-74-1,79299-12-0) + (5R,6R)-5-Hydroxy-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester (61377-97-7,79298-62-7,79298-68-3,79298-69-4,79298-70-7,79298-74-1,79299-12-0)

Guidance literature:

N-benzyl-trimethylammonium hydroxide; In dimethyl sulfoxide; for 30h; Ambient temperature;

DOI:10.1016/S0040-4020(01)97960-8

Reference yield:

oxepine-4-carboxylic acid tert-butyl ester (57078-21-4) + 3ξ-(4-methoxy-phenyl)-6-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione (61377-96-6,79298-60-5,79298-61-6,79298-67-2,98574-83-5) → (5RS)-5r-hydroxy-6t-[(1SR)-3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester (61377-97-7,79298-62-7,79298-68-3,79298-69-4,79298-70-7,79298-74-1,79299-12-0)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In dimethyl sulfoxide;

DOI:10.1021/ja00437a063

upstream raw materials:

4-carbo-t-butoxyoxepin

(1R,3R,5R)-3-(4-Methoxy-phenyl)-6-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

1-methylpiperazin-2,5-dione

1-Methoxymethyl-4-methyl-piperazine-2,5-dione

Downstream raw materials:

(5RS)-5r-acetoxy-6t-[(1SR)-3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester

4-benzyloxymethyl-7c-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione

(1RS)-6-((1SR)-6t-acetoxy-2-hydroxymethyl-cyclohexa-2,4-dien-r-yl)-3ξ-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

(1RS)-6-((1SR)-6t-acetoxy-2-chloromethyl-cyclohexa-2,4-dien-r-yl)-3ξ-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

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